MIR3148

Summary

MIR3148 (microRNA 3148, HGNC:38215) is a microRNA gene on chromosome 8p12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422876 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38215
Approved symbol	MIR3148
Name	microRNA 3148
Location	8p12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3148
Ensembl gene	ENSG00000264788
Ensembl biotype	miRNA
Entrez	100422876
RNAcentral	URS000075B414 — ncRNA, 77 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579676

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579676 — 1 exons

Exon	Start	End
ENSE00002710769	29957272	29957348

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 76.42.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.42	gold quality
monocyte	CL:0000576	74.91	gold quality
calcaneal tendon	UBERON:0003701	73.12	gold quality
tibial artery	UBERON:0007610	70.06	gold quality
right frontal lobe	UBERON:0002810	68.00	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.06	gold quality
left lobe of thyroid gland	UBERON:0001120	61.64	gold quality
thyroid gland	UBERON:0002046	58.47	gold quality
right lobe of thyroid gland	UBERON:0001119	57.49	gold quality
left testis	UBERON:0004533	40.05	gold quality
right testis	UBERON:0004534	37.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Reduced modulation by miR-3148 conferred slower degradation of the risk G-allele containing TLR7 transcripts. These data establish rs3853839 of TLR7 as a shared risk variant of SLE(systemic lupus erythematosus ) (PMID:23468661)
• MiR-3148 may play an important role in the development of CTEPH. The key mechanisms for this miRNA may be hsa-miR-3148-AR-pathways in cancer or hsa-miR-3148-PRKCA-pathways in cancer/glioma/ErbB signaling pathway. (PMID:28904974)
• High miR3148 expression is associated with colon Cancer. (PMID:30275189)
• BRD7-Mediated miR-3148 Inhibits Progression of Cervical Cancer by Targeting Wnt3a/beta-Catenin Pathway. (PMID:32046432)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.