MIR3149

Summary

MIR3149 (microRNA 3149, HGNC:38251) is a microRNA gene on chromosome 8q21.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422921 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38251
Approved symbol	MIR3149
Name	microRNA 3149
Location	8q21.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3149
Ensembl gene	ENSG00000266712
Ensembl biotype	miRNA
Entrez	100422921
RNAcentral	URS000079A8E5 — miRNA, 83 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584629

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584629 — 1 exons

Exon	Start	End
ENSE00002708369	76966768	76966850

Expression profiles

Bgee: expression breadth ubiquitous, 140 present calls, max score 89.12.

Top tissues by expression

231 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.12	gold quality
vermiform appendix	UBERON:0001154	80.45	gold quality
muscle of leg	UBERON:0001383	78.71	gold quality
gastrocnemius	UBERON:0001388	78.55	gold quality
adrenal tissue	UBERON:0018303	77.69	gold quality
leukocyte	CL:0000738	75.77	gold quality
monocyte	CL:0000576	75.50	gold quality
right uterine tube	UBERON:0001302	74.70	gold quality
rectum	UBERON:0001052	74.39	gold quality
right lung	UBERON:0002167	74.07	gold quality
granulocyte	CL:0000094	73.74	gold quality
smooth muscle tissue	UBERON:0001135	73.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	72.55	gold quality
islet of Langerhans	UBERON:0000006	72.39	gold quality
calcaneal tendon	UBERON:0003701	72.27	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.85	gold quality
left adrenal gland	UBERON:0001234	71.78	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.20	gold quality
right atrium auricular region	UBERON:0006631	71.03	gold quality
popliteal artery	UBERON:0002250	70.68	gold quality
tibial artery	UBERON:0007610	70.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.39	gold quality
body of stomach	UBERON:0001161	70.26	gold quality
right adrenal gland cortex	UBERON:0035827	70.24	gold quality
transverse colon	UBERON:0001157	69.78	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.76	gold quality
left coronary artery	UBERON:0001626	69.72	gold quality
anterior cingulate cortex	UBERON:0009835	69.63	gold quality
body of uterus	UBERON:0009853	69.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Plasma miR-122, miR-140-3p, miR-720, miR-2861, and miR-3149 were associated with and potentially novel biomarkers for acute coronary syndrome. (PMID:25933289)
• Further origin identification revealed that the expression levels of miR-122 in CECs and lymphocytes, miR-140-3p and -2861 in monocytes and CECs, miR-720 in monocytes, and miR-3149 in CECs were greatly up-regulated in the ACS patients compared with the non-ACS patients (PMID:28961259)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.