MIR3150A

Summary

MIR3150A (microRNA 3150a, HGNC:38362) is a microRNA gene on chromosome 8q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422964 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38362
Approved symbol	MIR3150A
Name	microRNA 3150a
Location	8q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3150, hsa-mir-3150a
Ensembl gene	ENSG00000283522
Ensembl biotype	miRNA
Entrez	100422964
RNAcentral	URS000075C3A0 — miRNA, 80 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636546

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636546 — 1 exons

Exon	Start	End
ENSE00003796075	95072914	95072993

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Overexpression of miR-3150a-3p decreased ACAN expression in nucleus pulposus cells, whereas inhibition of miR-3150a-3p increased ACAN expression. In addition, ACAN expression was negatively correlated with intervertebral disc degeneration (IDD) grade. The reduction of ACAN expression induced by the upregulation of miR-3150a-3p might participate in the development of IDD. (PMID:29554650)
• MiR-3150b-3p inhibits the progression of colorectal cancer cells via targeting GOLPH3. (PMID:31678970)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.