MIR3150B

Summary

MIR3150B (microRNA 3150b, HGNC:38938) is a microRNA gene on chromosome 8q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500907 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38938
Approved symbol	MIR3150B
Name	microRNA 3150b
Location	8q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3150b
Ensembl gene	ENSG00000284147
Ensembl biotype	miRNA
Entrez	100500907
RNAcentral	URS000075A34F — miRNA, 86 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580142

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580142 — 1 exons

Exon	Start	End
ENSE00002697562	95072911	95072996

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 85.92.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	85.92	gold quality
body of pancreas	UBERON:0001150	65.84	gold quality
skin of leg	UBERON:0001511	61.90	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.15	gold quality
tibial nerve	UBERON:0001323	60.03	gold quality
spleen	UBERON:0002106	55.38	gold quality
testis	UBERON:0000473	46.03	gold quality
left testis	UBERON:0004533	42.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA RP11-116G8.5 promotes the progression of lung squamous cell carcinoma through sponging miR-3150b-3p/miR-6870-5p to upregulate PHF12/FOXP4. (PMID:34500373)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.