MIR3151

Summary

MIR3151 (microRNA 3151, HGNC:38266) is a microRNA gene on chromosome 8q22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422992 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38266
Approved symbol	MIR3151
Name	microRNA 3151
Location	8q22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3151
Ensembl gene	ENSG00000265657
Ensembl biotype	miRNA
Entrez	100422992
RNAcentral	URS000075C6C0 — miRNA, 76 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583423

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583423 — 1 exons

Exon	Start	End
ENSE00002719005	103154614	103154689

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 68.55.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagogastric junction muscularis propria	UBERON:0035841	68.55	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.37	gold quality
tibial artery	UBERON:0007610	67.42	gold quality
skin of abdomen	UBERON:0001416	64.72	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.47	gold quality
skin of leg	UBERON:0001511	60.34	gold quality
cerebellar hemisphere	UBERON:0002245	60.33	gold quality
putamen	UBERON:0001874	59.39	gold quality
left lobe of thyroid gland	UBERON:0001120	54.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• high expression of miR-3151 is an independent prognosticator for poor outcome in cytogenetically normal-AML and affects different outcome end points than its host gene, BAALC (PMID:22529287)
• miR-3151 introns within BAALC have roles in driving leukemogenesis by deregulating the TP53 pathway (PMID:24736457)
• miR-3151 emerged as independent prognostic marker in younger patients with acute myeloid leukemia (PMID:26430723)
• miR-3151 silencing by DNA methylation protected chronic lymphocytic leukemia cells from apoptosis by over-expression of its direct targets MADD and PIK3R2, constitutive activation of MEK/ERK and PI3K/AKT signaling , and over-expression of MCL1. (PMID:26517243)
• Characterization of TP53 as a downstream effector of miR-3151 provides evidence for a causal link between BRAF mutations and TP53 inactivation (PMID:26582795)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.