MIR3153

Summary

MIR3153 (microRNA 3153, HGNC:38289) is a microRNA gene on chromosome 9q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422936 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38289
Approved symbol	MIR3153
Name	microRNA 3153
Location	9q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3153
Ensembl gene	ENSG00000265112
Ensembl biotype	miRNA
Entrez	100422936
RNAcentral	URS000075F026 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580744

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580744 — 1 exons

Exon	Start	End
ENSE00002695992	89312225	89312306

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 99.23.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.23	gold quality
adrenal tissue	UBERON:0018303	91.78	gold quality
bone marrow	UBERON:0002371	91.56	gold quality
granulocyte	CL:0000094	84.34	gold quality
duodenum	UBERON:0002114	84.10	gold quality
endometrium	UBERON:0001295	84.01	gold quality
tonsil	UBERON:0002372	83.90	gold quality
placenta	UBERON:0001987	82.69	gold quality
vermiform appendix	UBERON:0001154	81.06	gold quality
monocyte	CL:0000576	78.13	gold quality
lymph node	UBERON:0000029	77.15	gold quality
rectum	UBERON:0001052	77.11	gold quality
adrenal gland	UBERON:0002369	76.19	gold quality
blood	UBERON:0000178	75.58	gold quality
right adrenal gland cortex	UBERON:0035827	75.56	gold quality
heart left ventricle	UBERON:0002084	74.85	gold quality
left adrenal gland cortex	UBERON:0035825	74.64	gold quality
lower esophagus mucosa	UBERON:0035834	74.64	gold quality
urinary bladder	UBERON:0001255	74.13	gold quality
muscle of leg	UBERON:0001383	73.91	gold quality
heart	UBERON:0000948	73.46	gold quality
islet of Langerhans	UBERON:0000006	73.44	gold quality
right adrenal gland	UBERON:0001233	73.25	gold quality
left adrenal gland	UBERON:0001234	72.85	gold quality
kidney	UBERON:0002113	72.84	gold quality
stomach	UBERON:0000945	72.45	gold quality
gastrocnemius	UBERON:0001388	72.35	gold quality
liver	UBERON:0002107	72.10	gold quality
right lobe of liver	UBERON:0001114	72.02	gold quality
transverse colon	UBERON:0001157	71.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.