MIR3154

Summary

MIR3154 (microRNA 3154, HGNC:38176) is a microRNA gene on chromosome 9q34.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422893 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38176
Approved symbol	MIR3154
Name	microRNA 3154
Location	9q34.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3154
Ensembl gene	ENSG00000264823
Ensembl biotype	miRNA
Entrez	100422893
RNAcentral	URS000075BF1B — miRNA, 84 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577829

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577829 — 1 exons

Exon	Start	End
ENSE00002696099	128244947	128245030

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 82.39.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.39	gold quality
blood	UBERON:0000178	77.99	gold quality
lung	UBERON:0002048	75.70	gold quality
heart left ventricle	UBERON:0002084	72.75	gold quality
body of pancreas	UBERON:0001150	70.36	gold quality
tibial artery	UBERON:0007610	70.24	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.21	gold quality
putamen	UBERON:0001874	69.18	gold quality
endometrium	UBERON:0001295	68.89	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.42	gold quality
adenohypophysis	UBERON:0002196	67.83	gold quality
right atrium auricular region	UBERON:0006631	67.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.71	gold quality
substantia nigra	UBERON:0002038	66.69	gold quality
amygdala	UBERON:0001876	66.38	gold quality
hypothalamus	UBERON:0001898	66.31	gold quality
Ammon’s horn	UBERON:0001954	65.87	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.87	gold quality
transverse colon	UBERON:0001157	65.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.15	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.15	gold quality
myometrium	UBERON:0001296	65.07	gold quality
minor salivary gland	UBERON:0001830	64.81	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.47	gold quality
cerebellar hemisphere	UBERON:0002245	64.38	gold quality
body of uterus	UBERON:0009853	64.26	gold quality
endocervix	UBERON:0000458	64.24	gold quality
vagina	UBERON:0000996	63.84	gold quality
cerebral cortex	UBERON:0000956	63.83	gold quality
esophagus mucosa	UBERON:0002469	63.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Integrative miRNA analysis identified Hsa-miR-3754 and hsa-miR-7-3 significantly associated with shortened survival time and more death cases of patients with cervical neoplasm. These miRNA are potential prognostic targets for cervical cancer. (PMID:28771797)
• miR-3154 promotes hepatocellular carcinoma progression via suppressing HNF4alpha. (PMID:35917569)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.