MIR3156-3

Summary

MIR3156-3 (microRNA 3156-3, HGNC:38229) is a microRNA gene on chromosome 21q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423018 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38229
Approved symbol	MIR3156-3
Name	microRNA 3156-3
Location	21q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3156-3
Ensembl gene	ENSG00000266211
Ensembl biotype	miRNA
Entrez	100423018
RNAcentral	URS000075C752 — miRNA, 77 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580304

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580304 — 1 exons

Exon	Start	End
ENSE00002697578	13406384	13406460

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 57.14.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
omental fat pad	UBERON:0010414	57.14	gold quality
Ammon’s horn	UBERON:0001954	55.24	gold quality
tibial nerve	UBERON:0001323	54.45	gold quality
transverse colon	UBERON:0001157	52.77	gold quality
nucleus accumbens	UBERON:0001882	49.79	gold quality
lung	UBERON:0002048	45.28	gold quality
right testis	UBERON:0004534	28.36	silver quality
left testis	UBERON:0004533	28.35	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• These findings indicate that miR-3156-3p plays a suppressor-miRNA role in cervical cancer and that its expression is associated with high-risk human papillomavirus infection. (PMID:28160779)
• Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis. (PMID:33999360)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.