MIR3157

Summary

MIR3157 (microRNA 3157, HGNC:38172) is a microRNA gene on chromosome 10q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422892 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38172
Approved symbol	MIR3157
Name	microRNA 3157
Location	10q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3157
Ensembl gene	ENSG00000266407
Ensembl biotype	miRNA
Entrez	100422892
RNAcentral	URS000075CBE4 — ncRNA, 85 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578688

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578688 — 1 exons

Exon	Start	End
ENSE00002716351	96064315	96064399

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 83.66.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	83.66	gold quality
kidney	UBERON:0002113	82.71	gold quality
blood	UBERON:0000178	78.34	gold quality
monocyte	CL:0000576	75.86	gold quality
heart left ventricle	UBERON:0002084	74.87	gold quality
muscle of leg	UBERON:0001383	74.16	gold quality
gastrocnemius	UBERON:0001388	73.23	gold quality
islet of Langerhans	UBERON:0000006	72.47	gold quality
calcaneal tendon	UBERON:0003701	72.09	gold quality
lung	UBERON:0002048	71.98	gold quality
heart	UBERON:0000948	71.61	gold quality
liver	UBERON:0002107	71.60	gold quality
lymph node	UBERON:0000029	71.53	gold quality
stomach	UBERON:0000945	71.51	gold quality
body of pancreas	UBERON:0001150	69.55	gold quality
right atrium auricular region	UBERON:0006631	69.36	gold quality
endometrium	UBERON:0001295	68.62	gold quality
fundus of stomach	UBERON:0001160	68.09	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.09	gold quality
body of stomach	UBERON:0001161	67.75	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.66	gold quality
tibial artery	UBERON:0007610	67.41	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.25	gold quality
left coronary artery	UBERON:0001626	66.99	gold quality
left ovary	UBERON:0002119	66.91	gold quality
left adrenal gland	UBERON:0001234	66.90	gold quality
intestine	UBERON:0000160	66.86	gold quality
nucleus accumbens	UBERON:0001882	66.81	gold quality
Ammon’s horn	UBERON:0001954	66.72	gold quality
thoracic aorta	UBERON:0001515	66.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer. (PMID:34497265)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.