MIR3158-2

Summary

MIR3158-2 (microRNA 3158-2, HGNC:38279) is a microRNA gene on chromosome 10q24.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423033 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38279
Approved symbol	MIR3158-2
Name	microRNA 3158-2
Location	10q24.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3158-2
Ensembl gene	ENSG00000283558
Ensembl biotype	miRNA
Entrez	100423033
RNAcentral	URS000075F0B6 — miRNA, 81 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637571

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637571 — 1 exons

Exon	Start	End
ENSE00003798917	101601417	101601497

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 75.31.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	75.31	gold quality
sural nerve	UBERON:0015488	71.81	gold quality
liver	UBERON:0002107	69.17	gold quality
monocyte	CL:0000576	65.61	gold quality
tibial artery	UBERON:0007610	65.11	gold quality
calcaneal tendon	UBERON:0003701	64.63	gold quality
body of stomach	UBERON:0001161	64.01	gold quality
ascending aorta	UBERON:0001496	63.40	gold quality
fundus of stomach	UBERON:0001160	61.49	gold quality
esophagus	UBERON:0001043	61.31	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.57	gold quality
skin of abdomen	UBERON:0001416	58.24	gold quality
vagina	UBERON:0000996	57.70	gold quality
stomach	UBERON:0000945	56.95	gold quality
skin of leg	UBERON:0001511	56.90	gold quality
right lobe of thyroid gland	UBERON:0001119	56.73	gold quality
tibial nerve	UBERON:0001323	56.43	gold quality
left ovary	UBERON:0002119	56.33	gold quality
subcutaneous adipose tissue	UBERON:0002190	55.98	gold quality
putamen	UBERON:0001874	55.96	gold quality
left lobe of thyroid gland	UBERON:0001120	55.59	gold quality
hypothalamus	UBERON:0001898	55.38	gold quality
omental fat pad	UBERON:0010414	54.32	gold quality
thyroid gland	UBERON:0002046	53.78	gold quality
small intestine Peyer’s patch	UBERON:0003454	52.87	gold quality
transverse colon	UBERON:0001157	52.66	gold quality
nucleus accumbens	UBERON:0001882	52.66	gold quality
pituitary gland	UBERON:0000007	50.03	gold quality
thoracic mammary gland	UBERON:0005200	46.73	gold quality
corpus callosum	UBERON:0002336	41.61	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Plasma levels of hsa-miR-3158-3p microRNA on admission correlate with MRI findings and predict outcome in cerebral malaria. (PMID:34185402)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.