MIR3159

Summary

MIR3159 (microRNA 3159, HGNC:38181) is a microRNA gene on chromosome 11p15.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423016 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38181
Approved symbol	MIR3159
Name	microRNA 3159
Location	11p15.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3159
Ensembl gene	ENSG00000264603
Ensembl biotype	miRNA
Entrez	100423016
RNAcentral	URS000075C9AA — ncRNA, 74 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584572

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584572 — 1 exons

Exon	Start	End
ENSE00002695674	18387787	18387860

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 78.95.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	78.95	gold quality
adrenal tissue	UBERON:0018303	75.93	gold quality
muscle of leg	UBERON:0001383	74.26	gold quality
blood	UBERON:0000178	72.42	gold quality
gastrocnemius	UBERON:0001388	72.36	gold quality
monocyte	CL:0000576	71.91	gold quality
metanephros cortex	UBERON:0010533	71.50	gold quality
heart	UBERON:0000948	71.31	gold quality
endometrium	UBERON:0001295	71.19	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.15	gold quality
heart left ventricle	UBERON:0002084	71.06	gold quality
stomach	UBERON:0000945	68.15	gold quality
body of pancreas	UBERON:0001150	67.97	gold quality
substantia nigra	UBERON:0002038	67.86	gold quality
body of stomach	UBERON:0001161	67.74	gold quality
endocervix	UBERON:0000458	67.67	gold quality
left adrenal gland cortex	UBERON:0035825	67.56	gold quality
Ammon’s horn	UBERON:0001954	67.48	gold quality
adrenal gland	UBERON:0002369	67.27	gold quality
right lobe of thyroid gland	UBERON:0001119	66.72	gold quality
fundus of stomach	UBERON:0001160	66.41	gold quality
left adrenal gland	UBERON:0001234	66.40	gold quality
anterior cingulate cortex	UBERON:0009835	66.32	gold quality
tibial artery	UBERON:0007610	66.20	gold quality
ascending aorta	UBERON:0001496	65.16	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.07	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.86	gold quality
hypothalamus	UBERON:0001898	64.85	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.62	gold quality
amygdala	UBERON:0001876	64.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.