MIR3161

Summary

MIR3161 (microRNA 3161, HGNC:38285) is a microRNA gene on chromosome 11p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423000 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38285
Approved symbol	MIR3161
Name	microRNA 3161
Location	11p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3161
Ensembl gene	ENSG00000263693
Ensembl biotype	miRNA
Entrez	100423000
RNAcentral	URS000075A390 — miRNA, 77 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577977

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577977 — 1 exons

Exon	Start	End
ENSE00002721847	48096782	48096858

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 88.94.

Top tissues by expression

67 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	88.94	gold quality
blood	UBERON:0000178	83.30	gold quality
monocyte	CL:0000576	79.29	gold quality
bone marrow	UBERON:0002371	77.46	gold quality
adrenal tissue	UBERON:0018303	76.37	gold quality
muscle of leg	UBERON:0001383	74.96	gold quality
islet of Langerhans	UBERON:0000006	74.30	gold quality
gastrocnemius	UBERON:0001388	72.69	gold quality
stomach	UBERON:0000945	71.63	gold quality
heart	UBERON:0000948	71.47	gold quality
liver	UBERON:0002107	71.12	gold quality
multicellular organism	UBERON:0000468	70.81	gold quality
right atrium auricular region	UBERON:0006631	68.99	gold quality
substantia nigra	UBERON:0002038	68.29	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.73	gold quality
heart left ventricle	UBERON:0002084	67.55	gold quality
body of stomach	UBERON:0001161	67.44	gold quality
endometrium	UBERON:0001295	67.31	gold quality
transverse colon	UBERON:0001157	66.98	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.73	gold quality
intestine	UBERON:0000160	66.68	gold quality
right lobe of liver	UBERON:0001114	66.04	gold quality
colon	UBERON:0001155	65.44	gold quality
left adrenal gland cortex	UBERON:0035825	65.34	gold quality
tibial artery	UBERON:0007610	65.24	gold quality
ascending aorta	UBERON:0001496	65.12	gold quality
body of pancreas	UBERON:0001150	65.11	gold quality
minor salivary gland	UBERON:0001830	65.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.04	gold quality
cerebellar hemisphere	UBERON:0002245	65.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A 3’ Untranslated Region Polymorphism of CTNNB1 (Rs2953) Alters MiR-3161 Binding and Affects the Risk of Ischemic Stroke and Coronary Artery Disease in Chinese Han Population. (PMID:33789307)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.