MIR3162

Summary

MIR3162 (microRNA 3162, HGNC:38271) is a microRNA gene on chromosome 11q12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422880 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38271
Approved symbol	MIR3162
Name	microRNA 3162
Location	11q12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3162
Ensembl gene	ENSG00000264559
Ensembl biotype	miRNA
Entrez	100422880
RNAcentral	URS000075EF55 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581818

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581818 — 1 exons

Exon	Start	End
ENSE00002695222	59595077	59595158

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 78.60.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.60	gold quality
kidney	UBERON:0002113	77.74	gold quality
monocyte	CL:0000576	76.26	gold quality
adrenal tissue	UBERON:0018303	76.25	gold quality
endometrium	UBERON:0001295	75.88	gold quality
liver	UBERON:0002107	75.59	gold quality
anterior cingulate cortex	UBERON:0009835	74.93	gold quality
bone marrow	UBERON:0002371	74.89	gold quality
stomach	UBERON:0000945	73.74	gold quality
islet of Langerhans	UBERON:0000006	73.47	gold quality
gastrocnemius	UBERON:0001388	73.40	gold quality
adult mammalian kidney	UBERON:0000082	73.05	gold quality
calcaneal tendon	UBERON:0003701	72.29	gold quality
right ovary	UBERON:0002118	72.17	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.73	gold quality
heart	UBERON:0000948	70.00	gold quality
heart left ventricle	UBERON:0002084	69.22	gold quality
thoracic mammary gland	UBERON:0005200	68.95	gold quality
body of pancreas	UBERON:0001150	68.17	gold quality
corpus callosum	UBERON:0002336	68.16	gold quality
left adrenal gland cortex	UBERON:0035825	67.91	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.48	gold quality
right lobe of liver	UBERON:0001114	67.21	gold quality
tibial artery	UBERON:0007610	66.86	gold quality
left adrenal gland	UBERON:0001234	66.76	gold quality
intestine	UBERON:0000160	66.46	gold quality
ascending aorta	UBERON:0001496	66.33	gold quality
esophagus mucosa	UBERON:0002469	66.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.64	gold quality
right atrium auricular region	UBERON:0006631	65.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• These findings suggest a novel relationship between miR-3162-3p and beta-catenin and clarify their mechanistic role in asthma etiopathogenesis. (PMID:26959414)
• In HIV-1 IIIB-MT2 system, the levels of miR-3162-3p also decreased along with infection duration in vitro. Sensitivity and specificity for miR-3162-3p to distinguish new infection from old infection were 100.0% and 71.43%, respectively, with the cut-off value of 0.916. (PMID:29627523)
• study provides an insight into possible involvement of miR-3162-5p in [prostate cancer (PCa) etiology by targeting KLKs and AR. It highlights clinical utility of miR-3162-5p and its interactive axis as a new class of biomarkers and therapeutic targets for PCa (PMID:31018918)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.