MIR3163

Summary

MIR3163 (microRNA 3163, HGNC:38209) is a microRNA gene on chromosome 11q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423029 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38209
Approved symbol	MIR3163
Name	microRNA 3163
Location	11q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3163
Ensembl gene	ENSG00000266423
Ensembl biotype	miRNA
Entrez	100423029
RNAcentral	URS000075A0BF — ncRNA, 73 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581592

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581592 — 1 exons

Exon	Start	End
ENSE00002727489	66934434	66934506

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 81.40.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	81.40	gold quality
monocyte	CL:0000576	78.13	gold quality
prefrontal cortex	UBERON:0000451	75.16	gold quality
lung	UBERON:0002048	73.97	gold quality
liver	UBERON:0002107	73.82	gold quality
gastrocnemius	UBERON:0001388	73.19	gold quality
endometrium	UBERON:0001295	72.56	gold quality
kidney	UBERON:0002113	72.12	gold quality
left adrenal gland cortex	UBERON:0035825	70.99	gold quality
right atrium auricular region	UBERON:0006631	70.51	gold quality
stomach	UBERON:0000945	70.21	gold quality
body of stomach	UBERON:0001161	69.69	gold quality
nucleus accumbens	UBERON:0001882	69.64	gold quality
blood	UBERON:0000178	69.57	gold quality
rectum	UBERON:0001052	69.07	gold quality
right lobe of liver	UBERON:0001114	68.29	gold quality
left adrenal gland	UBERON:0001234	68.28	gold quality
putamen	UBERON:0001874	67.84	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.15	gold quality
tibial artery	UBERON:0007610	66.93	gold quality
minor salivary gland	UBERON:0001830	65.75	gold quality
adult mammalian kidney	UBERON:0000082	65.27	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.25	gold quality
substantia nigra	UBERON:0002038	65.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.12	gold quality
thoracic mammary gland	UBERON:0005200	65.09	gold quality
left ovary	UBERON:0002119	65.03	gold quality
left coronary artery	UBERON:0001626	64.79	gold quality
Ammon’s horn	UBERON:0001954	64.34	gold quality
omental fat pad	UBERON:0010414	64.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Data suggest that mternally expressed gene 3 (Meg3) long non-coding RNA and microRNA miR-3163 may coordinate suppression of translation of S-phase kinase associated protein 2 (Skp2) mRNA in non-small cell lung cancer (NSCLC) cells to inhibit cell growth. (PMID:26482610)
• MicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents. (PMID:31611551)
• DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/beta-catenin pathway. (PMID:33613108)
• Long Noncoding RNA CRNDE Functions as an Oncogene to Facilitate Aggressive Behaviors of Nasopharyngeal Carcinoma Cells by Modulating miR-3163/TWIST1 Axis. (PMID:34796452)
• LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway. (PMID:36591804)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.