MIR3165

Summary

MIR3165 (microRNA 3165, HGNC:38335) is a microRNA gene on chromosome 11q13.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422953 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38335
Approved symbol	MIR3165
Name	microRNA 3165
Location	11q13.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3165
Ensembl gene	ENSG00000263742
Ensembl biotype	miRNA
Entrez	100422953
RNAcentral	URS000075A4E1 — miRNA, 75 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579874

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579874 — 1 exons

Exon	Start	End
ENSE00002703995	72072228	72072302

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 83.83.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	83.83	gold quality
sural nerve	UBERON:0015488	82.06	gold quality
blood	UBERON:0000178	80.53	gold quality
adrenal tissue	UBERON:0018303	78.75	gold quality
gastrocnemius	UBERON:0001388	76.33	gold quality
stomach	UBERON:0000945	75.26	gold quality
monocyte	CL:0000576	74.76	gold quality
heart left ventricle	UBERON:0002084	71.91	gold quality
body of pancreas	UBERON:0001150	71.51	gold quality
putamen	UBERON:0001874	70.99	gold quality
corpus callosum	UBERON:0002336	69.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.51	gold quality
tibial artery	UBERON:0007610	67.88	gold quality
frontal cortex	UBERON:0001870	67.79	gold quality
endometrium	UBERON:0001295	67.77	gold quality
lung	UBERON:0002048	67.06	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.81	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.97	gold quality
skin of leg	UBERON:0001511	64.62	gold quality
upper lobe of left lung	UBERON:0008952	64.57	gold quality
right atrium auricular region	UBERON:0006631	64.43	gold quality
colon	UBERON:0001155	64.28	gold quality
tibial nerve	UBERON:0001323	64.18	gold quality
left adrenal gland	UBERON:0001234	64.09	gold quality
thoracic mammary gland	UBERON:0005200	63.90	gold quality
skin of abdomen	UBERON:0001416	63.78	gold quality
ascending aorta	UBERON:0001496	63.62	gold quality
vagina	UBERON:0000996	63.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.