MIR3166

Summary

MIR3166 (microRNA 3166, HGNC:38386) is a microRNA gene on chromosome 11q14.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423040 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38386
Approved symbol	MIR3166
Name	microRNA 3166
Location	11q14.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3166
Ensembl gene	ENSG00000266581
Ensembl biotype	miRNA
Entrez	100423040
RNAcentral	URS0000759AF0 — miRNA, 92 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577344

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577344 — 1 exons

Exon	Start	End
ENSE00002715315	88176502	88176593

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 74.08.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	74.08	gold quality
gastrocnemius	UBERON:0001388	73.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.67	gold quality
intestine	UBERON:0000160	71.32	gold quality
ascending aorta	UBERON:0001496	67.59	gold quality
transverse colon	UBERON:0001157	67.13	gold quality
amygdala	UBERON:0001876	67.09	gold quality
body of stomach	UBERON:0001161	66.27	gold quality
putamen	UBERON:0001874	66.13	gold quality
omental fat pad	UBERON:0010414	65.54	gold quality
myometrium	UBERON:0001296	64.64	gold quality
thyroid gland	UBERON:0002046	64.59	gold quality
skin of abdomen	UBERON:0001416	63.71	gold quality
vagina	UBERON:0000996	62.48	gold quality
left adrenal gland	UBERON:0001234	62.27	gold quality
spleen	UBERON:0002106	62.15	gold quality
esophagus mucosa	UBERON:0002469	61.16	gold quality
tibial nerve	UBERON:0001323	60.45	gold quality
anterior cingulate cortex	UBERON:0009835	58.85	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.60	gold quality
lung	UBERON:0002048	57.91	gold quality
skin of leg	UBERON:0001511	57.32	gold quality
left adrenal gland cortex	UBERON:0035825	57.32	gold quality
upper lobe of left lung	UBERON:0008952	56.75	gold quality
right testis	UBERON:0004534	38.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.