MIR3168

Summary

MIR3168 (microRNA 3168, HGNC:38249) is a microRNA gene on chromosome 13q14.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422878 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38249
Approved symbol	MIR3168
Name	microRNA 3168
Location	13q14.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3168
Ensembl gene	ENSG00000264226
Ensembl biotype	miRNA
Entrez	100422878
RNAcentral	URS000075AFC1 — ncRNA, 82 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577639

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577639 — 1 exons

Exon	Start	End
ENSE00002716098	41101019	41101100

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 80.24.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	80.24	gold quality
calcaneal tendon	UBERON:0003701	79.10	gold quality
endometrium	UBERON:0001295	77.82	gold quality
adrenal tissue	UBERON:0018303	77.37	gold quality
blood	UBERON:0000178	76.40	gold quality
islet of Langerhans	UBERON:0000006	75.21	gold quality
monocyte	CL:0000576	75.17	gold quality
gastrocnemius	UBERON:0001388	72.15	gold quality
left coronary artery	UBERON:0001626	72.08	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.73	gold quality
stomach	UBERON:0000945	68.92	gold quality
adult mammalian kidney	UBERON:0000082	68.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.59	gold quality
heart left ventricle	UBERON:0002084	68.28	gold quality
urinary bladder	UBERON:0001255	68.25	gold quality
right atrium auricular region	UBERON:0006631	68.18	gold quality
granulocyte	CL:0000094	68.16	gold quality
body of stomach	UBERON:0001161	67.92	gold quality
adrenal gland	UBERON:0002369	67.83	gold quality
left adrenal gland cortex	UBERON:0035825	67.73	gold quality
tonsil	UBERON:0002372	67.40	gold quality
tibial artery	UBERON:0007610	67.21	gold quality
right coronary artery	UBERON:0001625	67.19	gold quality
popliteal artery	UBERON:0002250	67.18	gold quality
ascending aorta	UBERON:0001496	66.37	gold quality
fallopian tube	UBERON:0003889	66.37	gold quality
left adrenal gland	UBERON:0001234	66.15	gold quality
thoracic aorta	UBERON:0001515	66.14	gold quality
hypothalamus	UBERON:0001898	66.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer. (PMID:34011306)
• Brain-Derived Neurotrophic Factor Suppressed Proinflammatory Cytokines Secretion and Enhanced MicroRNA(miR)-3168 Expression in Macrophages. (PMID:35009001)
• miR-3168 promotes hepatocellular carcinoma progression via downregulating p53. (PMID:35926447)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.