MIR3170

Summary

MIR3170 (microRNA 3170, HGNC:38282) is a microRNA gene on chromosome 13q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422881 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38282
Approved symbol	MIR3170
Name	microRNA 3170
Location	13q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3170
Ensembl gene	ENSG00000263399
Ensembl biotype	miRNA
Entrez	100422881
RNAcentral	URS000075EDB0 — miRNA, 77 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582699

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582699 — 1 exons

Exon	Start	End
ENSE00002688620	98208524	98208600

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 84.45.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	84.45	gold quality
adrenal tissue	UBERON:0018303	80.76	gold quality
muscle of leg	UBERON:0001383	79.74	gold quality
blood	UBERON:0000178	79.30	gold quality
nucleus accumbens	UBERON:0001882	74.05	gold quality
stomach	UBERON:0000945	72.19	gold quality
heart	UBERON:0000948	71.99	gold quality
endometrium	UBERON:0001295	71.98	gold quality
right lobe of thyroid gland	UBERON:0001119	69.95	gold quality
body of pancreas	UBERON:0001150	68.94	gold quality
left adrenal gland	UBERON:0001234	68.50	gold quality
right atrium auricular region	UBERON:0006631	68.34	gold quality
apex of heart	UBERON:0002098	67.80	gold quality
substantia nigra	UBERON:0002038	67.31	gold quality
right frontal lobe	UBERON:0002810	66.80	gold quality
Ammon’s horn	UBERON:0001954	66.66	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.32	gold quality
left adrenal gland cortex	UBERON:0035825	66.06	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.58	gold quality
body of stomach	UBERON:0001161	65.47	gold quality
kidney	UBERON:0002113	65.05	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.97	gold quality
multicellular organism	UBERON:0000468	64.71	gold quality
left ovary	UBERON:0002119	64.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.12	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.99	gold quality
skin of leg	UBERON:0001511	63.80	gold quality
colon	UBERON:0001155	63.61	gold quality
omental fat pad	UBERON:0010414	63.30	gold quality
transverse colon	UBERON:0001157	63.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A Five-microRNA Signature as Risk Stratification System in Uterine Corpus Endometrial Carcinoma. (PMID:32748742)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.