MIR3171

Summary

MIR3171 (microRNA 3171, HGNC:38216) is a microRNA gene on chromosome 14q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422830 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38216
Approved symbol	MIR3171
Name	microRNA 3171
Location	14q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3171
Ensembl gene	ENSG00000264657
Ensembl biotype	miRNA
Entrez	100422830
RNAcentral	URS00007AB6A5 — ncRNA, 74 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584270

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584270 — 1 exons

Exon	Start	End
ENSE00002702961	27633205	27633278

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 80.06.

Top tissues by expression

7 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	80.06	gold quality
kidney	UBERON:0002113	78.19	gold quality
endometrium	UBERON:0001295	74.50	gold quality
adult mammalian kidney	UBERON:0000082	69.19	gold quality
nucleus accumbens	UBERON:0001882	67.49	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.94	gold quality
right frontal lobe	UBERON:0002810	58.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.35

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.