MIR3173

Summary

MIR3173 (microRNA 3173, HGNC:38174) is a microRNA gene on chromosome 14q32.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422981 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38174
Approved symbol	MIR3173
Name	microRNA 3173
Location	14q32.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3173
Ensembl gene	ENSG00000264607
Ensembl biotype	miRNA
Entrez	100422981
RNAcentral	URS000075C556 — miRNA, 68 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580810

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580810 — 1 exons

Exon	Start	End
ENSE00002696963	95137919	95137986

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 85.47.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	85.47	gold quality
prefrontal cortex	UBERON:0000451	82.76	gold quality
bone marrow	UBERON:0002371	82.03	gold quality
calcaneal tendon	UBERON:0003701	79.87	gold quality
adult mammalian kidney	UBERON:0000082	79.70	gold quality
adrenal tissue	UBERON:0018303	77.89	gold quality
blood	UBERON:0000178	77.68	gold quality
liver	UBERON:0002107	76.95	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.34	gold quality
monocyte	CL:0000576	75.88	gold quality
muscle of leg	UBERON:0001383	74.25	gold quality
stomach	UBERON:0000945	73.46	gold quality
gastrocnemius	UBERON:0001388	73.15	gold quality
lymph node	UBERON:0000029	73.01	gold quality
heart	UBERON:0000948	72.37	gold quality
islet of Langerhans	UBERON:0000006	71.27	gold quality
thoracic mammary gland	UBERON:0005200	71.06	gold quality
smooth muscle tissue	UBERON:0001135	70.96	gold quality
heart left ventricle	UBERON:0002084	70.75	gold quality
right lobe of liver	UBERON:0001114	70.22	gold quality
rectum	UBERON:0001052	70.14	gold quality
right atrium auricular region	UBERON:0006631	69.94	gold quality
left adrenal gland	UBERON:0001234	69.60	gold quality
putamen	UBERON:0001874	69.25	gold quality
body of stomach	UBERON:0001161	69.03	gold quality
frontal cortex	UBERON:0001870	69.01	gold quality
body of pancreas	UBERON:0001150	68.80	gold quality
amygdala	UBERON:0001876	68.77	gold quality
corpus callosum	UBERON:0002336	68.63	gold quality
intestine	UBERON:0000160	68.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.92

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Generally, this study indicates that miR-3173 negatively regulates PTK2 and inhibits proliferation and invasion of B-ALL cell lines. Thus, miR-3173 may represent a potential therapeutic molecule for B-ALL intervention. (PMID:29066351)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.