MIR3174

Summary

MIR3174 (microRNA 3174, HGNC:38264) is a microRNA gene on chromosome 15q26.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422841 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38264
Approved symbol	MIR3174
Name	microRNA 3174
Location	15q26.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3174
Ensembl gene	ENSG00000265871
Ensembl biotype	miRNA
Entrez	100422841
RNAcentral	URS000075DEEE — miRNA, 87 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583440

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583440 — 1 exons

Exon	Start	End
ENSE00002724112	90006755	90006841

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 86.23.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	86.23	gold quality
adrenal tissue	UBERON:0018303	85.98	gold quality
corpus callosum	UBERON:0002336	83.83	gold quality
blood	UBERON:0000178	81.55	gold quality
duodenum	UBERON:0002114	81.03	gold quality
granulocyte	CL:0000094	80.64	gold quality
vermiform appendix	UBERON:0001154	79.68	gold quality
bone marrow	UBERON:0002371	78.91	gold quality
kidney	UBERON:0002113	78.59	gold quality
lymph node	UBERON:0000029	76.27	gold quality
muscle of leg	UBERON:0001383	74.89	gold quality
endometrium	UBERON:0001295	74.44	gold quality
prefrontal cortex	UBERON:0000451	74.06	gold quality
stomach	UBERON:0000945	73.89	gold quality
gastrocnemius	UBERON:0001388	73.85	gold quality
body of pancreas	UBERON:0001150	73.47	gold quality
islet of Langerhans	UBERON:0000006	73.29	gold quality
liver	UBERON:0002107	72.40	gold quality
adrenal gland	UBERON:0002369	72.10	gold quality
ectocervix	UBERON:0012249	71.30	gold quality
calcaneal tendon	UBERON:0003701	71.16	gold quality
heart	UBERON:0000948	70.81	gold quality
rectum	UBERON:0001052	70.48	gold quality
body of stomach	UBERON:0001161	70.42	gold quality
mucosa of transverse colon	UBERON:0004991	70.42	gold quality
intestine	UBERON:0000160	70.32	gold quality
transverse colon	UBERON:0001157	70.17	gold quality
placenta	UBERON:0001987	70.17	gold quality
heart left ventricle	UBERON:0002084	70.16	gold quality
tibial artery	UBERON:0007610	69.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.45

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• MiR-3174 functions as an oncogene in rectal cancer by targeting PCBD2. (PMID:30964167)
• MiR-3174 promotes proliferation and inhibits apoptosis by targeting FOXO1 in hepatocellular carcinoma. (PMID:32279994)
• Cisatracurium inhibits the proliferation, migration and invasion of breast cancer cells by regulating the expression of miR-3174. (PMID:33040777)
• LINC00958/miR-3174/PHF6 axis is responsible for triggering proliferation, migration and invasion of endometrial cancer. (PMID:34859848)
• miR-3174 Is a New Tumor Suppressor MicroRNA That Inhibits Several Tumor-Promoting Genes in Glioblastoma. (PMID:37298284)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.