MIR3175

Summary

MIR3175 (microRNA 3175, HGNC:38299) is a microRNA gene on chromosome 15q26.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422995 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38299
Approved symbol	MIR3175
Name	microRNA 3175
Location	15q26.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3175
Ensembl gene	ENSG00000284324
Ensembl biotype	miRNA
Entrez	100422995
RNAcentral	URS000075BEC9 — miRNA, 77 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577670

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577670 — 1 exons

Exon	Start	End
ENSE00002720853	92904399	92904475

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 89.25.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.25	gold quality
adult mammalian kidney	UBERON:0000082	87.85	gold quality
blood	UBERON:0000178	83.36	gold quality
kidney	UBERON:0002113	83.08	gold quality
adrenal tissue	UBERON:0018303	82.76	gold quality
bone marrow	UBERON:0002371	80.31	gold quality
liver	UBERON:0002107	79.47	gold quality
calcaneal tendon	UBERON:0003701	74.60	gold quality
gastrocnemius	UBERON:0001388	73.36	gold quality
heart	UBERON:0000948	72.11	gold quality
monocyte	CL:0000576	72.08	gold quality
lung	UBERON:0002048	72.08	gold quality
tibial nerve	UBERON:0001323	71.57	gold quality
stomach	UBERON:0000945	71.20	gold quality
body of pancreas	UBERON:0001150	69.34	gold quality
body of uterus	UBERON:0009853	69.04	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.61	gold quality
right atrium auricular region	UBERON:0006631	67.94	gold quality
tibial artery	UBERON:0007610	67.88	gold quality
ascending aorta	UBERON:0001496	67.80	gold quality
myometrium	UBERON:0001296	67.74	gold quality
colon	UBERON:0001155	67.71	gold quality
popliteal artery	UBERON:0002250	67.69	gold quality
heart left ventricle	UBERON:0002084	67.58	gold quality
corpus callosum	UBERON:0002336	67.44	gold quality
nucleus accumbens	UBERON:0001882	67.28	gold quality
Ammon’s horn	UBERON:0001954	67.14	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.14	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.66	gold quality
body of stomach	UBERON:0001161	65.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.67

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• HOXB1 functions as a tumor suppressor, regulated by miR-3175 in glioma. (PMID:26565624)
• MiR-3175 promotes epithelial-mesenchymal transition by targeting Smad7 in human conjunctiva and pterygium. (PMID:31774554)
• High miR3175 expression is associated with glioma. (PMID:31983121)
• Silencing of microRNA-3175 represses cell proliferation and invasion in prostate cancer by targeting the potential tumor-suppressor SCN4B. (PMID:32833340)
• DCAF1-targeting microRNA-3175 activates Nrf2 signaling and inhibits dexamethasone-induced oxidative injury in human osteoblasts. (PMID:34716304)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.