MIR3176

Summary

MIR3176 (microRNA 3176, HGNC:38345) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423037 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38345
Approved symbol	MIR3176
Name	microRNA 3176
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3176
Ensembl gene	ENSG00000266235
Ensembl biotype	miRNA
Entrez	100423037
RNAcentral	URS000075C750 — miRNA, 90 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582210

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582210 — 1 exons

Exon	Start	End
ENSE00002732314	543277	543366

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 97.76.

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	97.76	gold quality
sural nerve	UBERON:0015488	93.68	gold quality
endometrium	UBERON:0001295	93.64	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.53	gold quality
metanephros cortex	UBERON:0010533	89.43	gold quality
cerebellar hemisphere	UBERON:0002245	88.05	gold quality
adrenal tissue	UBERON:0018303	87.60	gold quality
lower esophagus mucosa	UBERON:0035834	86.02	gold quality
bone marrow	UBERON:0002371	85.93	gold quality
skeletal muscle tissue	UBERON:0001134	84.70	gold quality
transverse colon	UBERON:0001157	84.13	gold quality
body of pancreas	UBERON:0001150	83.67	gold quality
body of stomach	UBERON:0001161	83.59	gold quality
pancreas	UBERON:0001264	83.55	gold quality
small intestine Peyer’s patch	UBERON:0003454	83.54	gold quality
stomach	UBERON:0000945	83.40	gold quality
duodenum	UBERON:0002114	83.35	gold quality
small intestine	UBERON:0002108	83.30	gold quality
kidney	UBERON:0002113	82.33	gold quality
vermiform appendix	UBERON:0001154	82.10	gold quality
left adrenal gland cortex	UBERON:0035825	82.00	gold quality
intestine	UBERON:0000160	81.71	gold quality
colon	UBERON:0001155	81.28	gold quality
liver	UBERON:0002107	81.21	gold quality
pituitary gland	UBERON:0000007	81.13	gold quality
adult mammalian kidney	UBERON:0000082	81.04	gold quality
fundus of stomach	UBERON:0001160	81.02	gold quality
right lobe of liver	UBERON:0001114	80.83	gold quality
leukocyte	CL:0000738	80.55	gold quality
right uterine tube	UBERON:0001302	80.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.14

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.