MIR3177

Summary

MIR3177 (microRNA 3177, HGNC:38364) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423012 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38364
Approved symbol	MIR3177
Name	microRNA 3177
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3177
Ensembl gene	ENSG00000265820
Ensembl biotype	miRNA
Entrez	100423012
RNAcentral	URS000075D049 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578255

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578255 — 1 exons

Exon	Start	End
ENSE00002692417	1734985	1735066

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 81.54.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	81.54	gold quality
blood	UBERON:0000178	78.76	gold quality
adrenal tissue	UBERON:0018303	78.64	gold quality
bone marrow	UBERON:0002371	77.78	gold quality
muscle of leg	UBERON:0001383	74.73	gold quality
monocyte	CL:0000576	74.41	gold quality
gastrocnemius	UBERON:0001388	74.20	gold quality
lymph node	UBERON:0000029	72.92	gold quality
cerebellar hemisphere	UBERON:0002245	72.50	gold quality
stomach	UBERON:0000945	72.35	gold quality
endometrium	UBERON:0001295	72.17	gold quality
body of stomach	UBERON:0001161	71.91	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.93	gold quality
heart left ventricle	UBERON:0002084	70.63	gold quality
liver	UBERON:0002107	70.15	gold quality
heart	UBERON:0000948	70.08	gold quality
skin of abdomen	UBERON:0001416	69.88	gold quality
urinary bladder	UBERON:0001255	69.60	gold quality
body of pancreas	UBERON:0001150	69.54	gold quality
zone of skin	UBERON:0000014	68.96	gold quality
right atrium auricular region	UBERON:0006631	68.65	gold quality
adult mammalian kidney	UBERON:0000082	68.50	gold quality
kidney	UBERON:0002113	68.50	gold quality
prefrontal cortex	UBERON:0000451	68.47	gold quality
skin of leg	UBERON:0001511	68.25	gold quality
frontal cortex	UBERON:0001870	68.24	gold quality
ectocervix	UBERON:0012249	68.19	gold quality
minor salivary gland	UBERON:0001830	68.11	gold quality
left coronary artery	UBERON:0001626	68.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• hsa-miR-3177-3p demonstrated significantly lower levels in patients without vasospasm after aneurysmal subarachnoid hemorrhage compared with patients with vasospasm. (PMID:30354977)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.