MIR3178

Summary

MIR3178 (microRNA 3178, HGNC:38381) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422974 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38381
Approved symbol	MIR3178
Name	microRNA 3178
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3178
Ensembl gene	ENSG00000266232
Ensembl biotype	miRNA
Entrez	100422974
RNAcentral	URS000075B49B — ncRNA, 84 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581887

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581887 — 1 exons

Exon	Start	End
ENSE00002722304	2531922	2532005

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 80.23.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.23	gold quality
calcaneal tendon	UBERON:0003701	79.08	gold quality
right uterine tube	UBERON:0001302	78.56	gold quality
monocyte	CL:0000576	78.04	gold quality
blood	UBERON:0000178	76.82	gold quality
granulocyte	CL:0000094	76.67	gold quality
right hemisphere of cerebellum	UBERON:0014890	76.33	gold quality
cerebellar hemisphere	UBERON:0002245	75.04	gold quality
muscle of leg	UBERON:0001383	73.80	gold quality
prefrontal cortex	UBERON:0000451	73.55	gold quality
gastrocnemius	UBERON:0001388	72.91	gold quality
right adrenal gland cortex	UBERON:0035827	72.66	gold quality
heart left ventricle	UBERON:0002084	72.22	gold quality
left lobe of thyroid gland	UBERON:0001120	72.13	gold quality
thyroid gland	UBERON:0002046	71.54	gold quality
right adrenal gland	UBERON:0001233	71.51	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.13	gold quality
stomach	UBERON:0000945	70.66	gold quality
right lobe of thyroid gland	UBERON:0001119	70.61	gold quality
body of stomach	UBERON:0001161	70.39	gold quality
left adrenal gland cortex	UBERON:0035825	70.38	gold quality
heart	UBERON:0000948	69.92	gold quality
body of pancreas	UBERON:0001150	69.74	gold quality
saliva-secreting gland	UBERON:0001044	69.65	gold quality
ectocervix	UBERON:0012249	69.61	gold quality
minor salivary gland	UBERON:0001830	69.36	gold quality
endometrium	UBERON:0001295	69.34	gold quality
transverse colon	UBERON:0001157	69.11	gold quality
tibial artery	UBERON:0007610	69.05	gold quality
fallopian tube	UBERON:0003889	68.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• MiR-3178 has significantly low expression in hepatocellular carcinoma tumor endothelial cells.MiR-3178 acts as a tumor suppressor to inhibit tumorigenesis and metastasis.MiR-3178 inhibits angiogenesis of hepatocellular carcinoma tumor endothelial cells. (PMID:26182877)
• Taken all together, Helicobacter pylori toxin Tip-alpha might activate NF-kappaB to promote inflammation and carcinogenesis by inhibiting miR-3178 expression, which directly targets TRAF3, during Helicobacter pylori infection in gastric mucosal epithelial cells. (PMID:27493095)
• miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer. (PMID:30333478)
• mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase. (PMID:31285446)
• miR-3178 as a prognostic indicator and tumor suppressor of gastric cancer. (PMID:33547612)
• miR-3,178 contributes to the therapeutic action of baicalein against hepatocellular carcinoma cells via modulating HDAC10. (PMID:36070933)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.