MIR3179-3

Summary

MIR3179-3 (microRNA 3179-3, HGNC:38214) is a microRNA gene on chromosome 16p12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423006 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38214
Approved symbol	MIR3179-3
Name	microRNA 3179-3
Location	16p12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3179-3
Ensembl gene	ENSG00000266454
Ensembl biotype	miRNA
Entrez	100423006
RNAcentral	URS000064A21C — miRNA, 84 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579566

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579566 — 1 exons

Exon	Start	End
ENSE00002694315	18411894	18411977

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 59.95.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	59.95	gold quality
right atrium auricular region	UBERON:0006631	57.12	gold quality
nucleus accumbens	UBERON:0001882	55.73	gold quality
left adrenal gland	UBERON:0001234	54.73	gold quality
esophagus mucosa	UBERON:0002469	50.29	gold quality
blood	UBERON:0000178	48.51	silver quality
ascending aorta	UBERON:0001496	48.44	gold quality
tibial artery	UBERON:0007610	48.05	gold quality
transverse colon	UBERON:0001157	47.55	gold quality
muscle layer of sigmoid colon	UBERON:0035805	47.41	gold quality
subcutaneous adipose tissue	UBERON:0002190	47.09	gold quality
minor salivary gland	UBERON:0001830	47.03	gold quality
skin of abdomen	UBERON:0001416	45.40	gold quality
small intestine Peyer’s patch	UBERON:0003454	45.33	gold quality
skin of leg	UBERON:0001511	45.05	gold quality
spleen	UBERON:0002106	45.04	gold quality
body of stomach	UBERON:0001161	44.90	gold quality
Ammon’s horn	UBERON:0001954	44.86	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	44.74	gold quality
descending thoracic aorta	UBERON:0002345	44.21	gold quality
lower esophagus muscularis layer	UBERON:0035833	43.13	silver quality
body of pancreas	UBERON:0001150	43.11	silver quality
cerebellar hemisphere	UBERON:0002245	43.03	silver quality
tibial nerve	UBERON:0001323	42.35	gold quality
vagina	UBERON:0000996	42.10	gold quality
omental fat pad	UBERON:0010414	39.06	silver quality
caudate nucleus	UBERON:0001873	38.31	silver quality
anterior cingulate cortex	UBERON:0009835	37.72	silver quality
left lobe of thyroid gland	UBERON:0001120	37.46	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	35.59	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (3): MIR3179-2 (ENSG00000257381), MIR3179-4 (ENSG00000277014), MIR3179-1 (ENSG00000284305)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.