MIR3180-2

Summary

MIR3180-2 (microRNA 3180-2, HGNC:38343) is a microRNA gene on chromosome 16p13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422956 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38343
Approved symbol	MIR3180-2
Name	microRNA 3180-2
Location	16p13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3180-2
Ensembl gene	ENSG00000265373
Ensembl biotype	miRNA
Entrez	100422956
RNAcentral	URS000075A4D6 — miRNA, 88 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581748

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581748 — 1 exons

Exon	Start	End
ENSE00002726130	16309879	16309966

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 74.64.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	74.64	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.66	gold quality
nucleus accumbens	UBERON:0001882	69.63	gold quality
left adrenal gland	UBERON:0001234	66.36	gold quality
putamen	UBERON:0001874	63.55	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.30	gold quality
substantia nigra	UBERON:0002038	60.15	gold quality
cerebellar hemisphere	UBERON:0002245	60.04	gold quality
Ammon’s horn	UBERON:0001954	56.80	gold quality
skin of leg	UBERON:0001511	53.05	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	52.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.