MIR3180-5

Summary

MIR3180-5 (microRNA 3180-5, HGNC:38969) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500916 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38969
Approved symbol	MIR3180-5
Name	microRNA 3180-5
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3180-5
Ensembl gene	ENSG00000264397
Ensembl biotype	miRNA
Entrez	100500916
RNAcentral	URS000075C290 — miRNA, 153 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583743

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583743 — 1 exons

Exon	Start	End
ENSE00002701736	2135977	2136129

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 89.62.

Top tissues by expression

84 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.62	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.51	gold quality
endocervix	UBERON:0000458	74.18	gold quality
prefrontal cortex	UBERON:0000451	70.31	gold quality
adrenal tissue	UBERON:0018303	69.62	gold quality
blood	UBERON:0000178	69.40	gold quality
skeletal muscle tissue	UBERON:0001134	69.34	gold quality
muscle of leg	UBERON:0001383	68.00	gold quality
gastrocnemius	UBERON:0001388	67.71	gold quality
ectocervix	UBERON:0012249	66.61	gold quality
heart left ventricle	UBERON:0002084	66.53	gold quality
left coronary artery	UBERON:0001626	65.95	gold quality
popliteal artery	UBERON:0002250	65.19	gold quality
tibial artery	UBERON:0007610	65.14	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.82	gold quality
body of pancreas	UBERON:0001150	64.80	gold quality
stomach	UBERON:0000945	64.76	gold quality
right lobe of liver	UBERON:0001114	64.57	gold quality
liver	UBERON:0002107	64.34	gold quality
left adrenal gland cortex	UBERON:0035825	64.14	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.04	gold quality
thoracic aorta	UBERON:0001515	63.80	gold quality
ascending aorta	UBERON:0001496	63.64	gold quality
calcaneal tendon	UBERON:0003701	63.63	gold quality
right ovary	UBERON:0002118	63.17	gold quality
adult mammalian kidney	UBERON:0000082	63.13	gold quality
urinary bladder	UBERON:0001255	63.10	gold quality
body of uterus	UBERON:0009853	63.06	gold quality
cerebellar hemisphere	UBERON:0002245	62.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• It was apparent that HP upregulates miR-3180-5p, which inhibits the expression of PODN and promotes HBSMC proliferation via the cdk2 signaling pathway. (PMID:27608612)
• Serum miR-3180-3p and miR-124-3p may Function as Noninvasive Biomarkers of Cisplatin Resistance in Gastric Cancer. (PMID:33337849)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.