MIR3181

Summary

MIR3181 (microRNA 3181, HGNC:38378) is a microRNA gene on chromosome 16q12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422972 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38378
Approved symbol	MIR3181
Name	microRNA 3181
Location	16q12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3181
Ensembl gene	ENSG00000264947
Ensembl biotype	miRNA
Entrez	100422972
RNAcentral	URS00007E4A17 — ncRNA, 73 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578512

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578512 — 1 exons

Exon	Start	End
ENSE00002719739	50742305	50742377

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 94.17.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.17	gold quality
blood	UBERON:0000178	82.53	gold quality
granulocyte	CL:0000094	80.58	gold quality
liver	UBERON:0002107	77.07	gold quality
monocyte	CL:0000576	74.99	gold quality
leukocyte	CL:0000738	74.79	gold quality
right lobe of liver	UBERON:0001114	74.19	gold quality
skeletal muscle tissue	UBERON:0001134	74.01	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.90	gold quality
right adrenal gland cortex	UBERON:0035827	71.89	gold quality
gastrocnemius	UBERON:0001388	71.20	gold quality
heart left ventricle	UBERON:0002084	69.65	gold quality
endometrium	UBERON:0001295	69.57	gold quality
left adrenal gland	UBERON:0001234	68.93	gold quality
adult mammalian kidney	UBERON:0000082	68.57	gold quality
tibial artery	UBERON:0007610	67.84	gold quality
left adrenal gland cortex	UBERON:0035825	67.76	gold quality
heart	UBERON:0000948	67.65	gold quality
body of stomach	UBERON:0001161	67.23	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.95	gold quality
right atrium auricular region	UBERON:0006631	66.84	gold quality
stomach	UBERON:0000945	66.53	gold quality
lower esophagus	UBERON:0013473	66.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.18	gold quality
ascending aorta	UBERON:0001496	65.87	gold quality
skin of leg	UBERON:0001511	65.70	gold quality
thoracic aorta	UBERON:0001515	65.70	gold quality
tibial nerve	UBERON:0001323	65.51	gold quality
zone of skin	UBERON:0000014	65.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• hsa-miR-3181 is an epigenetic regulator of FCGRT expression (PMID:29302759)
• Expression profiles of miR3181 and miR199a in plasma and placenta of virally suppressed HIV-1 infected Cameroonian pregnant women at delivery. (PMID:35594307)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.