MIR3182

Summary

MIR3182 (microRNA 3182, HGNC:38317) is a microRNA gene on chromosome 16q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422853 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38317
Approved symbol	MIR3182
Name	microRNA 3182
Location	16q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3182
Ensembl gene	ENSG00000263785
Ensembl biotype	miRNA
Entrez	100422853
RNAcentral	URS000075B814 — ncRNA, 63 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580839

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580839 — 1 exons

Exon	Start	End
ENSE00002724568	83508346	83508408

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 82.27.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.27	gold quality
calcaneal tendon	UBERON:0003701	80.19	gold quality
adrenal tissue	UBERON:0018303	78.67	gold quality
muscle of leg	UBERON:0001383	78.08	gold quality
monocyte	CL:0000576	78.05	gold quality
gastrocnemius	UBERON:0001388	75.71	gold quality
heart left ventricle	UBERON:0002084	71.71	gold quality
heart	UBERON:0000948	71.69	gold quality
Ammon’s horn	UBERON:0001954	71.30	gold quality
apex of heart	UBERON:0002098	71.01	gold quality
blood	UBERON:0000178	70.66	gold quality
caudate nucleus	UBERON:0001873	70.63	gold quality
adult mammalian kidney	UBERON:0000082	70.55	gold quality
tibial artery	UBERON:0007610	69.52	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.39	gold quality
right atrium auricular region	UBERON:0006631	69.00	gold quality
esophagus mucosa	UBERON:0002469	68.79	gold quality
skin of abdomen	UBERON:0001416	67.09	gold quality
ascending aorta	UBERON:0001496	66.96	gold quality
ectocervix	UBERON:0012249	66.90	gold quality
amygdala	UBERON:0001876	66.82	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.27	gold quality
left coronary artery	UBERON:0001626	66.18	gold quality
skin of leg	UBERON:0001511	65.85	gold quality
omental fat pad	UBERON:0010414	65.58	gold quality
intestine	UBERON:0000160	64.88	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.63	gold quality
body of uterus	UBERON:0009853	64.54	gold quality
myometrium	UBERON:0001296	64.03	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• linc00858 acted as a competitive endogenous RNA to sponged miR-3182 and regulate MMP2 in lung cancer (PMID:31131637)
• We found that the three protein-coding genes functionally interact with targets of their intronic miRNAs, i.e., miR-3182, miR-6863, and miR-5582, in a tissue-specific pattern. (PMID:31464655)
• circUBAP2 exacerbates malignant capabilities of NSCLC by targeting KLF4 through miR-3182 modulation. (PMID:33882454)
• Evaluating the influence of Human Umbilical Cord Mesenchymal Stem Cells-derived exosomes loaded with miR-3182 on metastatic performance of Triple Negative Breast Cancer cells. (PMID:34614416)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.