MIR3183

Summary

MIR3183 (microRNA 3183, HGNC:38237) is a microRNA gene on chromosome 17p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422835 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38237
Approved symbol	MIR3183
Name	microRNA 3183
Location	17p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3183
Ensembl gene	ENSG00000264429
Ensembl biotype	miRNA
Entrez	100422835
RNAcentral	URS000075EA21 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578566

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578566 — 1 exons

Exon	Start	End
ENSE00002692326	1022476	1022559

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 80.11.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	80.11	gold quality
bone marrow	UBERON:0002371	79.41	gold quality
blood	UBERON:0000178	76.70	gold quality
muscle of leg	UBERON:0001383	74.92	gold quality
gastrocnemius	UBERON:0001388	74.14	gold quality
adrenal tissue	UBERON:0018303	73.46	gold quality
monocyte	CL:0000576	73.29	gold quality
prefrontal cortex	UBERON:0000451	72.97	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.23	gold quality
right atrium auricular region	UBERON:0006631	70.87	gold quality
heart left ventricle	UBERON:0002084	70.37	gold quality
heart	UBERON:0000948	70.32	gold quality
tibial artery	UBERON:0007610	70.24	gold quality
popliteal artery	UBERON:0002250	70.14	gold quality
islet of Langerhans	UBERON:0000006	70.11	gold quality
lymph node	UBERON:0000029	69.94	gold quality
ascending aorta	UBERON:0001496	69.79	gold quality
endometrium	UBERON:0001295	69.65	gold quality
thoracic aorta	UBERON:0001515	69.43	gold quality
stomach	UBERON:0000945	68.95	gold quality
transverse colon	UBERON:0001157	68.90	gold quality
body of stomach	UBERON:0001161	68.83	gold quality
colon	UBERON:0001155	68.43	gold quality
left coronary artery	UBERON:0001626	68.26	gold quality
intestine	UBERON:0000160	68.17	gold quality
ectocervix	UBERON:0012249	68.17	gold quality
minor salivary gland	UBERON:0001830	68.09	gold quality
anterior cingulate cortex	UBERON:0009835	67.92	gold quality
left uterine tube	UBERON:0001303	67.82	gold quality
esophagus mucosa	UBERON:0002469	67.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.