MIR3184

Summary

MIR3184 (microRNA 3184, HGNC:38182) is a microRNA gene on chromosome 17q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423003 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38182
Approved symbol	MIR3184
Name	microRNA 3184
Location	17q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3184
Ensembl gene	ENSG00000284399
Ensembl biotype	miRNA
Entrez	100423003
RNAcentral	URS000075AC72 — miRNA, 75 nt, 22 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637796

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637796 — 1 exons

Exon	Start	End
ENSE00003798673	30117086	30117160

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 80.17.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.17	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	71.08	gold quality
lung	UBERON:0002048	68.07	gold quality
skin of leg	UBERON:0001511	58.60	gold quality
cerebellar hemisphere	UBERON:0002245	52.31	gold quality
prostate gland	UBERON:0002367	49.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• MiR-3184-5p and miR-181c-3p are involved in regulation breast cancer progression/metastasis in obese patients. (PMID:30847933)
• paired box 5 (PAX5) transcriptionally activated FOXP4-AS1 and FOXP4 in prostate cancer. (PMID:31209207)
• ErbB2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53responsive microRNA31845p in cervical cancer cells. (PMID:33416166)
• LncRNA FOXP4-AS promotes the progression of non-small cell lung cancer by regulating the miR-3184-5p/EIF5A axis. (PMID:34921595)
• Exosome miR-3184-5p inhibits gastric cancer growth by targeting XBP1 to regulate the AKT, STAT3, and IRE1 signalling pathways. (PMID:35394683)
• miR-3184-3p enriched in cerebrospinal fluid exosomes contributes to progression of glioma and promotes M2-like macrophage polarization. (PMID:35411604)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.