MIR3186

Summary

MIR3186 (microRNA 3186, HGNC:38311) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422944 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38311
Approved symbol	MIR3186
Name	microRNA 3186
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3186
Ensembl gene	ENSG00000266189
Ensembl biotype	miRNA
Entrez	100422944
RNAcentral	URS000075F01B — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577404

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577404 — 1 exons

Exon	Start	End
ENSE00002701891	81451104	81451188

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 89.70.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	89.70	gold quality
cerebellar hemisphere	UBERON:0002245	86.74	gold quality
bone marrow	UBERON:0002371	86.42	gold quality
duodenum	UBERON:0002114	86.27	gold quality
right coronary artery	UBERON:0001625	83.45	gold quality
placenta	UBERON:0001987	81.70	gold quality
right lobe of thyroid gland	UBERON:0001119	80.81	gold quality
prefrontal cortex	UBERON:0000451	80.18	gold quality
vermiform appendix	UBERON:0001154	79.89	gold quality
smooth muscle tissue	UBERON:0001135	79.30	gold quality
descending thoracic aorta	UBERON:0002345	78.98	gold quality
left lobe of thyroid gland	UBERON:0001120	78.83	gold quality
thyroid gland	UBERON:0002046	78.57	gold quality
stomach	UBERON:0000945	78.54	gold quality
body of stomach	UBERON:0001161	78.53	gold quality
left uterine tube	UBERON:0001303	78.47	gold quality
right adrenal gland cortex	UBERON:0035827	77.99	gold quality
right adrenal gland	UBERON:0001233	77.96	gold quality
body of pancreas	UBERON:0001150	77.63	gold quality
pancreas	UBERON:0001264	77.36	gold quality
left ovary	UBERON:0002119	77.14	gold quality
fundus of stomach	UBERON:0001160	76.84	gold quality
endometrium	UBERON:0001295	76.82	gold quality
ovary	UBERON:0000992	76.70	gold quality
myometrium	UBERON:0001296	76.28	gold quality
right ovary	UBERON:0002118	76.04	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.04	gold quality
adrenal gland	UBERON:0002369	75.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	75.61	gold quality
lower esophagus	UBERON:0013473	75.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Circular RNA Eps15-homology domain containing protein 2 motivates proliferation, glycolysis but refrains autophagy in non-small cell lung cancer via crosstalk with microRNA-3186-3p and forkhead box K1. (PMID:35220908)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.