MIR3187

Summary

MIR3187 (microRNA 3187, HGNC:38319) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422854 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38319
Approved symbol	MIR3187
Name	microRNA 3187
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3187
Ensembl gene	ENSG00000263414
Ensembl biotype	miRNA
Entrez	100422854
RNAcentral	URS000075C4EE — ncRNA, 70 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583431

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583431 — 1 exons

Exon	Start	End
ENSE00003597486	813584	813653

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 76.59.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	76.59	gold quality
omental fat pad	UBERON:0010414	70.99	gold quality
tibial nerve	UBERON:0001323	70.10	gold quality
transverse colon	UBERON:0001157	70.05	gold quality
body of pancreas	UBERON:0001150	68.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.75	gold quality
blood	UBERON:0000178	68.71	gold quality
skin of abdomen	UBERON:0001416	64.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.36	gold quality
right atrium auricular region	UBERON:0006631	60.83	gold quality
left coronary artery	UBERON:0001626	60.53	gold quality
spleen	UBERON:0002106	59.24	gold quality
cerebellar hemisphere	UBERON:0002245	57.31	gold quality
upper lobe of left lung	UBERON:0008952	54.71	gold quality
thoracic mammary gland	UBERON:0005200	54.24	gold quality
substantia nigra	UBERON:0002038	49.68	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	49.50	gold quality
left ovary	UBERON:0002119	47.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Circulating serum exosomal miR-20b-5p and miR-3187-5p as efficient diagnostic biomarkers for early-stage non-small cell lung cancer. (PMID:32741216)
• Long non-coding RNA H19 promotes the proliferation, migration and invasion while inhibits apoptosis of hypertrophic scarring fibroblasts by targeting miR-3187-3p/GAB1 axis. (PMID:32888745)
• CircCDC6 restrains tumor growth and glycolysis energy metabolism in colorectal cancer via regulating miR-3187-3p and downstream PRKAA2. (PMID:35438362)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.