MIR3188

Summary

MIR3188 (microRNA 3188, HGNC:38226) is a microRNA gene on chromosome 19p13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422833 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38226
Approved symbol	MIR3188
Name	microRNA 3188
Location	19p13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3188
Ensembl gene	ENSG00000267959
Ensembl biotype	miRNA
Entrez	100422833
RNAcentral	URS000075E5AE — miRNA, 85 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583494

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583494 — 1 exons

Exon	Start	End
ENSE00002718412	18282077	18282161

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 87.47.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.3428 / max 273.0051, expressed in 924 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174638	5.3428	924

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.47	gold quality
vermiform appendix	UBERON:0001154	86.24	gold quality
monocyte	CL:0000576	85.70	gold quality
skeletal muscle tissue	UBERON:0001134	85.14	gold quality
duodenum	UBERON:0002114	80.68	gold quality
lymph node	UBERON:0000029	78.11	gold quality
blood	UBERON:0000178	77.34	gold quality
islet of Langerhans	UBERON:0000006	75.04	gold quality
calcaneal tendon	UBERON:0003701	75.02	gold quality
muscle of leg	UBERON:0001383	74.45	gold quality
bone marrow	UBERON:0002371	74.32	gold quality
liver	UBERON:0002107	73.65	gold quality
adrenal tissue	UBERON:0018303	73.10	gold quality
gastrocnemius	UBERON:0001388	73.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.09	gold quality
left uterine tube	UBERON:0001303	71.35	gold quality
endometrium	UBERON:0001295	70.79	gold quality
body of pancreas	UBERON:0001150	70.70	gold quality
adult mammalian kidney	UBERON:0000082	70.51	gold quality
placenta	UBERON:0001987	70.49	gold quality
right lobe of liver	UBERON:0001114	69.96	gold quality
urinary bladder	UBERON:0001255	69.55	gold quality
stomach	UBERON:0000945	69.36	gold quality
heart left ventricle	UBERON:0002084	69.07	gold quality
body of stomach	UBERON:0001161	68.95	gold quality
adrenal gland	UBERON:0002369	68.68	gold quality
right atrium auricular region	UBERON:0006631	68.65	gold quality
granulocyte	CL:0000094	68.61	gold quality
heart	UBERON:0000948	68.39	gold quality
left adrenal gland cortex	UBERON:0035825	68.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR-p-PI3K/AKT-c-JUN. (PMID:27095304)
• our study indicates that downregulation of miR-3188 may contribute to atherosclerosis development via negatively regulating Lp-PLA2, targeting ELK4 and activating the RhoA/ROCK pathway (PMID:29442044)
• Findings revealed that CAF-derived exosomes contain lower miR-3188 levels than NFs, and the loss of miR-3188 in exosomes contributes to the malignant phenotypes of HNC cells through the derepression of BCL2. (PMID:30961650)
• The miR-3188 (rs7247237-C>T) polymorphism is associated with the incidence of vascular complications in Chinese patients with type 2 diabetes. (PMID:31274844)
• miR-3188 Regulates proliferation and apoptosis of granulosa cells by targeting KCNA5 in the polycystic ovary syndrome. (PMID:33533580)
• The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci. (PMID:33805769)
• MiR-3188 regulates the proliferation and apoptosis of hepatocellular carcinoma cells by targeting CXCL14. (PMID:34704819)
• miR-3188 inhibits hepatitis B virus transcription by targeting Bcl-2. (PMID:38565755)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.