MIR3189

Summary

MIR3189 (microRNA 3189, HGNC:38307) is a microRNA gene on chromosome 19p13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422943 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38307
Approved symbol	MIR3189
Name	microRNA 3189
Location	19p13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3189
Ensembl gene	ENSG00000264175
Ensembl biotype	miRNA
Entrez	100422943
RNAcentral	URS000075DBDF — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578735

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578735 — 1 exons

Exon	Start	End
ENSE00002732859	18386562	18386634

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 94.81.

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
metanephros cortex	UBERON:0010533	94.81	gold quality
rectum	UBERON:0001052	92.10	gold quality
kidney	UBERON:0002113	91.75	gold quality
duodenum	UBERON:0002114	91.66	gold quality
adult mammalian kidney	UBERON:0000082	90.59	gold quality
placenta	UBERON:0001987	88.31	gold quality
urinary bladder	UBERON:0001255	86.78	gold quality
stomach	UBERON:0000945	86.35	gold quality
body of stomach	UBERON:0001161	85.79	gold quality
smooth muscle tissue	UBERON:0001135	85.14	gold quality
body of pancreas	UBERON:0001150	84.72	gold quality
prostate gland	UBERON:0002367	83.75	gold quality
pancreas	UBERON:0001264	83.03	gold quality
gall bladder	UBERON:0002110	82.15	gold quality
fundus of stomach	UBERON:0001160	81.81	gold quality
adrenal tissue	UBERON:0018303	80.15	gold quality
calcaneal tendon	UBERON:0003701	79.45	gold quality
liver	UBERON:0002107	79.13	gold quality
right lobe of liver	UBERON:0001114	78.69	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.64	gold quality
islet of Langerhans	UBERON:0000006	78.15	gold quality
blood	UBERON:0000178	77.54	gold quality
transverse colon	UBERON:0001157	76.92	gold quality
endometrium	UBERON:0001295	76.55	gold quality
endocervix	UBERON:0000458	76.21	gold quality
lung	UBERON:0002048	76.19	gold quality
gastrocnemius	UBERON:0001388	76.02	gold quality
adenohypophysis	UBERON:0002196	75.88	gold quality
colon	UBERON:0001155	75.59	gold quality
intestine	UBERON:0000160	74.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• miR-3189-3p-mediated inhibition of tumor growth in vivo further supports the function of this microRNA as a tumor suppressor. (PMID:25645911)
• miR-3189 is embedded in the intron of GDF15 gene. miR-3189 is a novel, primate-specific miRNA whose effects are mediated by both p53-dependent and p53-independent mechanisms. (PMID:25698447)
• miR-3189-3p mimics enhanced the effects of the S100A4 siRNA on the inhibition of gastric cancer cell proliferation and migration by targeting CFL2. (PMID:29342841)
• miR-3189-targeted GLUT3 repression by HDAC2 knockdown inhibits glioblastoma tumorigenesis through regulating glucose metabolism and proliferation. (PMID:35260183)
• A novel interplay between PRC2 and miR-3189 regulates epithelial-mesenchymal transition (EMT) via modulating COL6A2 in glioblastoma. (PMID:38860406)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.