MIR3190

Summary

MIR3190 (microRNA 3190, HGNC:38190) is a microRNA gene on chromosome 19q13.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422899 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38190
Approved symbol	MIR3190
Name	microRNA 3190
Location	19q13.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3190
Ensembl gene	ENSG00000265134
Ensembl biotype	miRNA
Entrez	100422899
RNAcentral	URS0000759B54 — miRNA, 80 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577414

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577414 — 1 exons

Exon	Start	End
ENSE00002707663	47226942	47227021

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 72.31.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	72.31	gold quality
muscle of leg	UBERON:0001383	71.72	gold quality
gastrocnemius	UBERON:0001388	67.87	gold quality
liver	UBERON:0002107	67.12	gold quality
omental fat pad	UBERON:0010414	65.98	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.10	gold quality
caudate nucleus	UBERON:0001873	64.65	gold quality
right atrium auricular region	UBERON:0006631	63.83	gold quality
tibial artery	UBERON:0007610	63.38	gold quality
esophagus mucosa	UBERON:0002469	63.13	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.65	gold quality
Brodmann (1909) area 9	UBERON:0013540	62.40	gold quality
putamen	UBERON:0001874	61.53	gold quality
left adrenal gland	UBERON:0001234	61.27	gold quality
hypothalamus	UBERON:0001898	60.47	gold quality
thyroid gland	UBERON:0002046	60.30	gold quality
body of pancreas	UBERON:0001150	60.29	gold quality
transverse colon	UBERON:0001157	59.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	57.33	gold quality
left adrenal gland cortex	UBERON:0035825	57.23	gold quality
body of stomach	UBERON:0001161	57.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	56.84	gold quality
heart left ventricle	UBERON:0002084	56.55	gold quality
skin of leg	UBERON:0001511	56.41	gold quality
small intestine Peyer’s patch	UBERON:0003454	56.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	55.61	gold quality
minor salivary gland	UBERON:0001830	55.31	gold quality
left ovary	UBERON:0002119	52.73	gold quality
prostate gland	UBERON:0002367	52.28	gold quality
body of uterus	UBERON:0009853	51.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.