MIR3191

Summary

MIR3191 (microRNA 3191, HGNC:38222) is a microRNA gene on chromosome 19q13.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422832 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38222
Approved symbol	MIR3191
Name	microRNA 3191
Location	19q13.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3191
Ensembl gene	ENSG00000284411
Ensembl biotype	miRNA
Entrez	100422832
RNAcentral	URS000075D085 — miRNA, 76 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636300

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636300 — 1 exons

Exon	Start	End
ENSE00003792660	47226944	47227019

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 82.95.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	82.95	gold quality
heart	UBERON:0000948	70.62	gold quality
hypothalamus	UBERON:0001898	70.15	gold quality
right lobe of liver	UBERON:0001114	70.09	gold quality
body of pancreas	UBERON:0001150	70.08	gold quality
transverse colon	UBERON:0001157	67.56	gold quality
heart left ventricle	UBERON:0002084	67.28	gold quality
blood	UBERON:0000178	66.81	gold quality
intestine	UBERON:0000160	66.77	gold quality
body of stomach	UBERON:0001161	66.00	gold quality
esophagus mucosa	UBERON:0002469	64.93	gold quality
gastrocnemius	UBERON:0001388	64.51	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.31	gold quality
Brodmann (1909) area 9	UBERON:0013540	62.36	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.05	gold quality
muscle layer of sigmoid colon	UBERON:0035805	60.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	58.15	gold quality
pituitary gland	UBERON:0000007	58.04	gold quality
right frontal lobe	UBERON:0002810	57.02	gold quality
vagina	UBERON:0000996	55.63	gold quality
skin of abdomen	UBERON:0001416	55.13	gold quality
omental fat pad	UBERON:0010414	55.00	gold quality
left adrenal gland cortex	UBERON:0035825	54.77	gold quality
right lobe of thyroid gland	UBERON:0001119	54.06	gold quality
skin of leg	UBERON:0001511	52.73	gold quality
tibial artery	UBERON:0007610	52.34	gold quality
left adrenal gland	UBERON:0001234	52.04	gold quality
tibial nerve	UBERON:0001323	51.95	gold quality
ascending aorta	UBERON:0001496	51.52	gold quality
subcutaneous adipose tissue	UBERON:0002190	50.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MicroRNA-3191 promotes migration and invasion by downregulating TGFBR2 in colorectal cancer. (PMID:30770602)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.