MIR3193

Summary

MIR3193 (microRNA 3193, HGNC:38204) is a microRNA gene on chromosome 20q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422904 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38204
Approved symbol	MIR3193
Name	microRNA 3193
Location	20q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3193
Ensembl gene	ENSG00000264395
Ensembl biotype	miRNA
Entrez	100422904
RNAcentral	URS000075EE94 — miRNA, 55 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578262

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578262 — 1 exons

Exon	Start	End
ENSE00002688044	31607186	31607240

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 80.01.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	80.01	gold quality
lymph node	UBERON:0000029	79.77	gold quality
rectum	UBERON:0001052	78.67	gold quality
adrenal tissue	UBERON:0018303	78.53	gold quality
calcaneal tendon	UBERON:0003701	78.22	gold quality
blood	UBERON:0000178	77.19	gold quality
right lung	UBERON:0002167	75.63	gold quality
urinary bladder	UBERON:0001255	74.74	gold quality
stomach	UBERON:0000945	74.41	gold quality
gastrocnemius	UBERON:0001388	74.07	gold quality
islet of Langerhans	UBERON:0000006	73.84	gold quality
placenta	UBERON:0001987	73.83	gold quality
lung	UBERON:0002048	73.77	gold quality
heart	UBERON:0000948	72.73	gold quality
heart left ventricle	UBERON:0002084	72.45	gold quality
kidney	UBERON:0002113	71.90	gold quality
liver	UBERON:0002107	71.36	gold quality
tibial artery	UBERON:0007610	71.33	gold quality
thoracic aorta	UBERON:0001515	71.32	gold quality
body of pancreas	UBERON:0001150	71.17	gold quality
Ammon’s horn	UBERON:0001954	71.09	gold quality
right atrium auricular region	UBERON:0006631	71.08	gold quality
body of uterus	UBERON:0009853	71.05	gold quality
ascending aorta	UBERON:0001496	71.02	gold quality
body of stomach	UBERON:0001161	71.00	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.84	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.79	gold quality
adult mammalian kidney	UBERON:0000082	70.75	gold quality
putamen	UBERON:0001874	70.72	gold quality
right adrenal gland cortex	UBERON:0035827	70.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Genome-wide methylation analyses identifies Non-coding RNA genes dysregulated in breast tumours that metastasise to the brain. (PMID:35058523)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.