MIR3194

Summary

MIR3194 (microRNA 3194, HGNC:38346) is a microRNA gene on chromosome 20q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422889 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38346
Approved symbol	MIR3194
Name	microRNA 3194
Location	20q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3194
Ensembl gene	ENSG00000266761
Ensembl biotype	miRNA
Entrez	100422889
RNAcentral	URS000075A4E2 — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582236

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582236 — 1 exons

Exon	Start	End
ENSE00002695047	51452905	51452977

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 86.65.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	86.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.19	gold quality
blood	UBERON:0000178	80.30	gold quality
lung	UBERON:0002048	79.40	gold quality
calcaneal tendon	UBERON:0003701	77.72	gold quality
gastrocnemius	UBERON:0001388	73.28	gold quality
stomach	UBERON:0000945	72.99	gold quality
heart left ventricle	UBERON:0002084	71.88	gold quality
heart	UBERON:0000948	69.85	gold quality
body of stomach	UBERON:0001161	69.67	gold quality
body of pancreas	UBERON:0001150	69.61	gold quality
tibial artery	UBERON:0007610	68.69	gold quality
multicellular organism	UBERON:0000468	68.30	gold quality
colon	UBERON:0001155	67.62	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.51	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.40	gold quality
endometrium	UBERON:0001295	67.33	gold quality
Ammon’s horn	UBERON:0001954	67.18	gold quality
granulocyte	CL:0000094	66.68	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.10	gold quality
ascending aorta	UBERON:0001496	65.94	gold quality
esophagus mucosa	UBERON:0002469	65.75	gold quality
transverse colon	UBERON:0001157	65.63	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.54	gold quality
omental fat pad	UBERON:0010414	64.61	gold quality
nucleus accumbens	UBERON:0001882	64.55	gold quality
putamen	UBERON:0001874	64.35	gold quality
caudate nucleus	UBERON:0001873	64.32	gold quality
skin of abdomen	UBERON:0001416	64.31	gold quality
substantia nigra	UBERON:0002038	63.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• High MIR3194 expression is associated with oropharyngeal cancer metastasis. (PMID:29663357)
• Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis. (PMID:34516362)
• Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression. (PMID:35034634)
• LINC00926 is involved in hypoxia-induced vascular endothelial cell dysfunction via miR-3194-5p regulating JAK1/STAT3 signaling pathway. (PMID:36647631)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.