MIR3196

Summary

MIR3196 (microRNA 3196, HGNC:38198) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423014 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38198
Approved symbol	MIR3196
Name	microRNA 3196
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3196
Ensembl gene	ENSG00000266463
Ensembl biotype	miRNA
Entrez	100423014
RNAcentral	URS000075DDDD — miRNA, 64 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579556

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579556 — 1 exons

Exon	Start	End
ENSE00002726346	63238779	63238842

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 94.95.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	94.95	gold quality
stomach	UBERON:0000945	78.27	gold quality
Ammon’s horn	UBERON:0001954	75.33	gold quality
heart left ventricle	UBERON:0002084	75.31	gold quality
tibial artery	UBERON:0007610	73.16	gold quality
right ovary	UBERON:0002118	70.79	gold quality
body of pancreas	UBERON:0001150	70.24	gold quality
tibial nerve	UBERON:0001323	69.82	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.03	gold quality
amygdala	UBERON:0001876	67.58	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.91	gold quality
adipose tissue	UBERON:0001013	66.87	gold quality
skin of leg	UBERON:0001511	66.73	gold quality
frontal cortex	UBERON:0001870	66.63	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.15	gold quality
left coronary artery	UBERON:0001626	66.13	gold quality
right frontal lobe	UBERON:0002810	65.88	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.79	gold quality
putamen	UBERON:0001874	65.65	gold quality
thoracic mammary gland	UBERON:0005200	65.46	gold quality
caudate nucleus	UBERON:0001873	65.34	gold quality
left adrenal gland	UBERON:0001234	65.18	gold quality
left adrenal gland cortex	UBERON:0035825	65.06	gold quality
skin of abdomen	UBERON:0001416	64.73	gold quality
omental fat pad	UBERON:0010414	64.47	gold quality
spleen	UBERON:0002106	64.36	gold quality
nucleus accumbens	UBERON:0001882	62.78	gold quality
hypothalamus	UBERON:0001898	61.82	gold quality
pituitary gland	UBERON:0000007	60.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Results show that gammaH2AX binds to the miR-3196 promoter which inhibits lung cancer cells apoptosis by downregulating PUMA its direct functional target. (PMID:27780918)
• Overexpression of miR-3196 could repress the proliferation and induce the apoptosis of breast cancer cells via targeting the 3’UTR of ERBB3. (PMID:30556879)
• Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression. (PMID:31235820)
• miR-3196 acts as a Tumor Suppressor and Predicts Survival Outcomes in Patients With Gastric Cancer. (PMID:32419651)
• Long noncoding RNA MAFG-AS1 facilitates the progression of hepatocellular carcinoma via targeting miR-3196/OTX1 axis. (PMID:33336731)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.