MIR3197

Summary

MIR3197 (microRNA 3197, HGNC:38366) is a microRNA gene on chromosome 21q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423023 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38366
Approved symbol	MIR3197
Name	microRNA 3197
Location	21q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3197
Ensembl gene	ENSG00000263681
Ensembl biotype	miRNA
Entrez	100423023
RNAcentral	URS000075D6BC — ncRNA, 73 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582241

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582241 — 1 exons

Exon	Start	End
ENSE00002698395	41167557	41167629

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 84.09.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1037 / max 12.5491, expressed in 41 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189209	0.1037	41

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	84.09	gold quality
prefrontal cortex	UBERON:0000451	75.16	gold quality
blood	UBERON:0000178	74.23	gold quality
monocyte	CL:0000576	73.15	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.09	gold quality
descending thoracic aorta	UBERON:0002345	72.94	gold quality
gastrocnemius	UBERON:0001388	72.62	gold quality
body of pancreas	UBERON:0001150	72.20	gold quality
prostate gland	UBERON:0002367	72.16	gold quality
anterior cingulate cortex	UBERON:0009835	71.62	gold quality
endometrium	UBERON:0001295	70.92	gold quality
body of stomach	UBERON:0001161	70.77	gold quality
stomach	UBERON:0000945	70.72	gold quality
heart left ventricle	UBERON:0002084	70.26	gold quality
tibial artery	UBERON:0007610	69.82	gold quality
popliteal artery	UBERON:0002250	69.79	gold quality
right atrium auricular region	UBERON:0006631	69.66	gold quality
thoracic aorta	UBERON:0001515	69.47	gold quality
ascending aorta	UBERON:0001496	69.36	gold quality
minor salivary gland	UBERON:0001830	69.21	gold quality
hypothalamus	UBERON:0001898	68.93	gold quality
putamen	UBERON:0001874	68.52	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.14	gold quality
adult mammalian kidney	UBERON:0000082	67.34	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.28	gold quality
kidney	UBERON:0002113	67.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.25	gold quality
left uterine tube	UBERON:0001303	67.20	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.12	gold quality
thoracic mammary gland	UBERON:0005200	66.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• both miR-3197 and miR-2116-5p were identified as promising diagnostic biomarkers for diabetic retinopathy (PMID:31678272)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.