MIR3198-1

Summary

MIR3198-1 (microRNA 3198-1, HGNC:38236) is a microRNA gene on chromosome 22q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423025 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38236
Approved symbol	MIR3198-1
Name	microRNA 3198-1
Location	22q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3198-1
Ensembl gene	ENSG00000264757
Ensembl biotype	miRNA
Entrez	100423025
RNAcentral	URS000075A8F7 — miRNA, 80 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583102

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583102 — 1 exons

Exon	Start	End
ENSE00002734587	17764180	17764259

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 73.61.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	73.61	gold quality
monocyte	CL:0000576	70.90	gold quality
right atrium auricular region	UBERON:0006631	69.11	gold quality
right frontal lobe	UBERON:0002810	67.91	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.45	gold quality
thoracic mammary gland	UBERON:0005200	67.39	gold quality
gastrocnemius	UBERON:0001388	65.96	gold quality
tibial artery	UBERON:0007610	65.91	gold quality
liver	UBERON:0002107	65.90	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.86	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.71	gold quality
left coronary artery	UBERON:0001626	64.31	gold quality
multicellular organism	UBERON:0000468	63.96	gold quality
left adrenal gland	UBERON:0001234	63.66	gold quality
body of stomach	UBERON:0001161	63.60	gold quality
upper lobe of left lung	UBERON:0008952	63.30	gold quality
esophagus mucosa	UBERON:0002469	63.29	gold quality
nucleus accumbens	UBERON:0001882	63.02	gold quality
right lobe of liver	UBERON:0001114	62.86	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.68	gold quality
skin of leg	UBERON:0001511	62.28	gold quality
caudate nucleus	UBERON:0001873	61.93	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.88	gold quality
tibial nerve	UBERON:0001323	61.81	gold quality
left ovary	UBERON:0002119	61.72	gold quality
vagina	UBERON:0000996	61.65	gold quality
myometrium	UBERON:0001296	61.65	gold quality
skin of abdomen	UBERON:0001416	61.31	gold quality
hypothalamus	UBERON:0001898	61.10	gold quality
amygdala	UBERON:0001876	61.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MiR-3198 is upregulated by compression and is downregulated by tension, suggesting that miR-3198 downregulates Osteoprotegerin expression in response to mechanical stress. (PMID:31041888)
• Exosomal encapsulation of miR-3198 promotes proliferation and migration of trophoblasts in preeclampsia. (PMID:38536597)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.