MIR3198-2

Summary

MIR3198-2 (microRNA 3198-2, HGNC:41766) is a microRNA gene on chromosome 12q13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616400 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41766
Approved symbol	MIR3198-2
Name	microRNA 3198-2
Location	12q13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3198-2
Ensembl gene	ENSG00000283803
Ensembl biotype	miRNA
Entrez	100616400
RNAcentral	URS000075E563 — miRNA, 80 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577868

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577868 — 1 exons

Exon	Start	End
ENSE00002699954	54231397	54231476

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 88.19.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	88.19	gold quality
right lobe of thyroid gland	UBERON:0001119	77.73	gold quality
testis	UBERON:0000473	76.84	gold quality
left lobe of thyroid gland	UBERON:0001120	75.58	gold quality
anterior cingulate cortex	UBERON:0009835	74.06	gold quality
heart left ventricle	UBERON:0002084	73.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.53	gold quality
blood	UBERON:0000178	67.69	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.36	gold quality
muscle of leg	UBERON:0001383	66.91	gold quality
gastrocnemius	UBERON:0001388	65.75	gold quality
endometrium	UBERON:0001295	65.65	gold quality
skin of leg	UBERON:0001511	62.93	gold quality
stomach	UBERON:0000945	61.31	gold quality
body of stomach	UBERON:0001161	61.02	gold quality
tibial artery	UBERON:0007610	58.55	gold quality
right frontal lobe	UBERON:0002810	57.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-3198 is upregulated by compression and is downregulated by tension, suggesting that miR-3198 downregulates Osteoprotegerin expression in response to mechanical stress. (PMID:31041888)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.