MIR3199-2

Summary

MIR3199-2 (microRNA 3199-2, HGNC:38205) is a microRNA gene on chromosome 22q12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422998 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38205
Approved symbol	MIR3199-2
Name	microRNA 3199-2
Location	22q12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3199-2
Ensembl gene	ENSG00000283225
Ensembl biotype	miRNA
Entrez	100422998
RNAcentral	URS000075B20A — miRNA, 86 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636243

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636243 — 1 exons

Exon	Start	End
ENSE00003794190	27920526	27920611

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 73.81.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagogastric junction muscularis propria	UBERON:0035841	73.81	gold quality
blood	UBERON:0000178	73.65	gold quality
intestine	UBERON:0000160	67.90	gold quality
ascending aorta	UBERON:0001496	64.94	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.93	gold quality
tibial artery	UBERON:0007610	64.34	gold quality
substantia nigra	UBERON:0002038	64.21	gold quality
hypothalamus	UBERON:0001898	64.19	gold quality
cerebellar hemisphere	UBERON:0002245	62.86	gold quality
body of pancreas	UBERON:0001150	62.81	gold quality
omental fat pad	UBERON:0010414	61.40	gold quality
left ovary	UBERON:0002119	61.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.33	gold quality
corpus callosum	UBERON:0002336	58.18	gold quality
right frontal lobe	UBERON:0002810	54.21	gold quality
left testis	UBERON:0004533	50.96	gold quality
testis	UBERON:0000473	46.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• hsa-mir-3199-2 and hsa-mir-1293 that can act as prognostic biomarkers of Papillary renal cell carcinoma were screened out, which can provide new insights for the clinical treatment of the disease. (PMID:28338236)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.