MIR31HG

Summary

MIR31HG (MIR31 host gene, HGNC:37187) is a long non-coding RNA gene on chromosome 9p21.3.

This gene produces a long non-coding RNA that acts as a host gene for miR-31. This transcript may be involved in cellular pluripotency and regulate the differentiation of myoblasts and other tissues. This RNA was found to interact with Polycomb repressive proteins to repression transcription of genes involves in cell senescence.

Source: NCBI Gene 554202 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37187
Approved symbol	MIR31HG
Name	MIR31 host gene
Location	9p21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC554202, hsa-lnc-31, LncHIFCAR
Ensembl gene	ENSG00000171889
Ensembl biotype	lncRNA
OMIM	616356
Entrez	554202
RNAcentral	URS0000CCDFB4 — lncRNA, 2266 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 56 lncRNA

ENST00000304425, ENST00000654736, ENST00000663833, ENST00000669680, ENST00000670459, ENST00000698342, ENST00000698343, ENST00000698344, ENST00000698345, ENST00000698346, ENST00000698347, ENST00000698348, ENST00000698349, ENST00000698350, ENST00000698373, ENST00000698374, ENST00000698375, ENST00000698376, ENST00000698377, ENST00000698378, ENST00000698379, ENST00000698380, ENST00000698394, ENST00000698395, ENST00000700956, ENST00000701417, ENST00000701930, ENST00000773559, ENST00000773560, ENST00000805437, ENST00000805438, ENST00000805439, ENST00000805440, ENST00000805441, ENST00000805442, ENST00000805443, ENST00000805444, ENST00000805445, ENST00000805446, ENST00000805447, ENST00000805448, ENST00000805449, ENST00000805450, ENST00000805451, ENST00000805452, ENST00000805453, ENST00000805454, ENST00000805455, ENST00000805456, ENST00000805457, ENST00000805458, ENST00000805459, ENST00000805460, ENST00000805461, ENST00000805462, ENST00000805463

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000304425 — 4 exons

Exon	Start	End
ENSE00001540342	21559489	21559831
ENSE00003973367	21477169	21477292
ENSE00003973374	21476899	21477035
ENSE00003973474	21453847	21455944

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 87.40.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.0433 / max 1075.2016, expressed in 998 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
100235	3.0873	913
100234	2.6677	586
100231	2.4265	547
100232	0.5183	241
100230	0.2727	146
100233	0.0708	23

Top tissues by expression

210 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.40	gold quality
stromal cell of endometrium	CL:0002255	75.28	gold quality
jejunal mucosa	UBERON:0000399	67.96	gold quality
colonic epithelium	UBERON:0000397	67.21	silver quality
lower esophagus mucosa	UBERON:0035834	67.20	gold quality
cartilage tissue	UBERON:0002418	67.10	gold quality
urinary bladder	UBERON:0001255	66.28	gold quality
duodenum	UBERON:0002114	66.05	gold quality
ectocervix	UBERON:0012249	65.13	gold quality
esophagus mucosa	UBERON:0002469	63.60	gold quality
endocervix	UBERON:0000458	63.21	gold quality
esophagus	UBERON:0001043	62.92	gold quality
vagina	UBERON:0000996	62.47	gold quality
islet of Langerhans	UBERON:0000006	62.31	gold quality
body of stomach	UBERON:0001161	60.22	gold quality
uterine cervix	UBERON:0000002	58.84	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	58.46	gold quality
pancreas	UBERON:0001264	58.09	gold quality
stomach	UBERON:0000945	58.05	gold quality
adenohypophysis	UBERON:0002196	57.74	gold quality
ventricular zone	UBERON:0003053	57.71	silver quality
Brodmann (1909) area 9	UBERON:0013540	56.82	gold quality
cerebellar cortex	UBERON:0002129	56.73	gold quality
ganglionic eminence	UBERON:0004023	56.64	silver quality
cerebellar hemisphere	UBERON:0002245	56.55	gold quality
prefrontal cortex	UBERON:0000451	56.49	gold quality
small intestine	UBERON:0002108	56.49	gold quality
pituitary gland	UBERON:0000007	56.09	gold quality
skin of hip	UBERON:0001554	56.00	silver quality
right uterine tube	UBERON:0001302	55.78	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	17.36
E-ANND-3	yes	9.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 36)

• Results indicate that MIR31HG functions as an oncogenic long noncoding RNAs (lncRNAs) that promotes tumor progression, and miR-193b targets not only protein-coding genes but also the lncRNA, MIR31HG. (PMID:26549028)
• MIR31HG expression is decreased in gastric cancer tissues and associated with larger tumor size and advanced pathological stage. Lower MIR31HG expression is associated with poorer prognosis. Ectopic over-expression of MIR31HG inhibits gastric cancer cell proliferation both in vitro and in vivo. MIR31HG knockdown by siRNA promoted cell proliferation in GC cells partly via regulating E2F1 and p21 expression. (PMID:26692098)
• MIR31HG regulates bone formation and inflammation via interacting with NF-kappaB. (PMID:27334046)
• MIR31HG is a HIF-1alpha co-activator that regulates the HIF-1 transcriptional network, crucial for cancer development.MIR31HG level is substantially upregulated in oral carcinoma, significantly associated with poor clinical outcomes and representing an independent prognostic predictor. (PMID:28639619)
• Inhibition of MIR31HG reduced the enrichment of active histone markers, histone H3 lysine 4 trimethylation (H3K4me3) and acetylation (AcH3), in the promoter of the adipogenic-related gene, fatty acid binding protein 4 (FABP4). (PMID:28808264)
• results in vivo confirmed the anti-tumour effects of knockdown of LOC554202, which inhibited EZH2/miR-31 to activate the oncogene RNF144B (PMID:28963737)
• observed that down-regulated MIR31HG in ESCC patients was associated with malignant clinical characteristics. MIR31HG might be considered as a potential prognostic indicator. (PMID:28975978)
• Loc554202 expression levels are significantly higher in cervical cancer and are predictive of poor prognosis in patients with cervical cancer. (PMID:29129878)
• MIR31HG high-expression is an independent unfavorable prognostic factor for lung adenocarcinoma patients, and serves an oncogenic role to modulate lung adenocarcinoma cells proliferation and cell-cycle. (PMID:29367106)
• MIR31HG can be used as a novel potential diagnostic biomarker and a potential therapeutic target for esophageal squamous cell carcinoma (PMID:29605445)
• The results demonstrated that the MIR31HG-miR-31-ITIH5-PIK3CG pathway plays a role in the pathogenesis of Hirschsprung disease. (PMID:29626357)
• Study present evidence that MIR31HG expression in colorectal cancer provides clinical stratification beyond major gene expression phenotypes and tumor immune and stromal cell infiltration and propose a model where increased expression is an indicator of a cellular state conferring intrinsic invasive and/or immuno-evasive capabilities. (PMID:30447009)
• The current results provide evidences for the role of MIR31HG in promoting HNSCC progression and identify MIR31HG as a prognostic biomarker and putative therapeutic target in HNSCC. (PMID:30458787)
• LncRNA LOC554202 expression is higher in gastric cancer (GC) cells than that of gastric mucosal cells. It could promote proliferative and migratory abilities by downregulating expression levels of p21 and E-cadherin in GC cells. However, how LOC554202 regulates the expressions of p21 and E-cadherin in GC cells remains to be further studied. (PMID:30575909)
• MIR31HG is upregulated in non small cell lung cancer tissues and cells.Upregulation of MIR31HG is obviously correlated with unfavorable survival.MIR31HG is a direct target of SP1.MIR31HG promotes non small cell lung cancer progression by sponging miR-214. (PMID:30659947)
• Significance of lncRNA MIR31HG in predicting the prognosis for Chinese patients with cancer: a meta-analysis. (PMID:32134327)
• Genetic variants of the MIR31HG gene are related to a risk of IgA nephropathy. (PMID:32344354)
• Clinical significance of lncRNA MIR31HG in melanoma. (PMID:32373976)
• LncRNA MIR31HG functions as a ceRNA to regulate c-Met function by sponging miR-34a in esophageal squamous cell carcinoma. (PMID:32502839)
• MIR31HG exhibits oncogenic property and acts as a sponge for miR-361-3p in cervical carcinoma. (PMID:32819595)
• Long noncoding RNA MIR31HG and its splice variants regulate proliferation and migration: prognostic implications for muscle invasive bladder cancer. (PMID:33334367)
• The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype. (PMID:33911076)
• MIR31HG regulates the proliferation, migration and invasion of breast cancer by regulating the expression of POLDIP2. (PMID:34076993)
• LncRNA MIR31HG Drives Oncogenicity by Inhibiting the Limb-Bud and Heart Development Gene (LBH) during Oral Carcinoma. (PMID:34445087)
• LncRNA MIR31HG is induced by tocilizumab and ameliorates rheumatoid arthritis fibroblast-like synoviocyte-mediated inflammation via miR-214-PTEN-AKT signaling pathway. (PMID:34753831)
• Long non-coding RNA MIR31HG as a prognostic predictor for malignant cancers: A meta- and bioinformatics analysis. (PMID:34837713)
• Long Noncoding RNA LOC554202 Predicts a Poor Prognosis and Correlates with Immune Infiltration in Thyroid Cancer. (PMID:35265169)
• Suppression of MIR31HG affects the functional properties of thyroid cancer cells depending on the miR-761/MAPK1 axis. (PMID:35443670)
• Association between MIR31HG polymorphisms and the risk of Lumbar disc herniation in Chinese Han population. (PMID:35704669)
• MIR31HG polymorphisms are related to steroid-induced osteonecrosis of femoral head among Chinese Han population. (PMID:36057712)
• The polymorphisms of MIR31HG gene is correlated with alcohol-induced osteonecrosis of the femoral head in Chinese Han male population. (PMID:36506078)
• Impact of MIR31HG polymorphisms on risk of breast cancer in Chinese women. (PMID:36884100)
• lncRNA MIR31HG Regulates Proliferation and Migration by Targeting Matrix Gla Protein in Nonsyndromic Cleft Lip With or Without Cleft Palate. (PMID:37327028)
• LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression. (PMID:37950038)
• LncRNA MIR31HG promotes cell proliferation and invasive properties of the MCF-7 cell line by regulation of receptor-interacting serine-threonine kinase 4. (PMID:38064252)
• Expression profile of long-noncoding RNAs MIR31HG, NKILA, and PACER in systemic lupus erythematosus patients. (PMID:38395324)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.