MIR3200

Summary

MIR3200 (microRNA 3200, HGNC:38227) is a microRNA gene on chromosome 22q12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422912 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38227
Approved symbol	MIR3200
Name	microRNA 3200
Location	22q12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3200
Ensembl gene	ENSG00000264661
Ensembl biotype	miRNA
Entrez	100422912
RNAcentral	URS000075CE96 — miRNA, 85 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580767

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580767 — 1 exons

Exon	Start	End
ENSE00002711060	30731557	30731641

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 84.13.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	84.13	gold quality
blood	UBERON:0000178	82.30	gold quality
skeletal muscle tissue	UBERON:0001134	81.76	gold quality
monocyte	CL:0000576	77.37	gold quality
muscle of leg	UBERON:0001383	76.94	gold quality
gastrocnemius	UBERON:0001388	74.61	gold quality
right atrium auricular region	UBERON:0006631	70.40	gold quality
heart	UBERON:0000948	70.08	gold quality
stomach	UBERON:0000945	68.98	gold quality
body of pancreas	UBERON:0001150	68.87	gold quality
heart left ventricle	UBERON:0002084	67.91	gold quality
lung	UBERON:0002048	67.72	gold quality
substantia nigra	UBERON:0002038	67.65	gold quality
omental fat pad	UBERON:0010414	67.39	gold quality
Ammon’s horn	UBERON:0001954	67.35	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.33	gold quality
left adrenal gland	UBERON:0001234	67.11	gold quality
tibial artery	UBERON:0007610	66.75	gold quality
right lobe of thyroid gland	UBERON:0001119	66.19	gold quality
ascending aorta	UBERON:0001496	66.02	gold quality
left adrenal gland cortex	UBERON:0035825	65.56	gold quality
zone of skin	UBERON:0000014	65.50	gold quality
body of stomach	UBERON:0001161	65.47	gold quality
skin of abdomen	UBERON:0001416	65.37	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.36	gold quality
skin of leg	UBERON:0001511	65.33	gold quality
thoracic mammary gland	UBERON:0005200	64.97	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.97	gold quality
esophagus mucosa	UBERON:0002469	64.93	gold quality
transverse colon	UBERON:0001157	64.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• overexpression of miR-3200-5p significantly decreased BRMS1 levels and promoted OS cell invasion and migration, while depletion of miR-3200-5p significantly increased BRMS1 levels and inhibited OS cell invasion and migration. Study revealed that miR-3200-5p may be a critical regulator of OS cell invasiveness. (PMID:29890825)
• Circular RNA MTO1 suppresses tumorigenesis of gastric carcinoma by sponging miR-3200-5p and targeting PEBP1. (PMID:32194149)
• LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis. (PMID:34596006)
• MicroRNA-3200-3p targeting CAMK2A modulates the proliferation and metastasis of glioma in vitro. (PMID:35287547)
• Downregulation of HULC Induces Ferroptosis in Hepatocellular Carcinoma via Targeting of the miR-3200-5p/ATF4 Axis. (PMID:35615577)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.