MIR3202-1

Summary

MIR3202-1 (microRNA 3202-1, HGNC:38224) is a microRNA gene on chromosome Xq28.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422987 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38224
Approved symbol	MIR3202-1
Name	microRNA 3202-1
Location	Xq28
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3202-1
Ensembl gene	ENSG00000265176
Ensembl biotype	miRNA
Entrez	100422987
RNAcentral	URS000075E36E — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580198

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580198 — 1 exons

Exon	Start	End
ENSE00002727544	153981097	153981177

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 79.16.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	79.16	gold quality
muscle of leg	UBERON:0001383	74.25	gold quality
mucosa of transverse colon	UBERON:0004991	73.42	gold quality
blood	UBERON:0000178	72.67	gold quality
sural nerve	UBERON:0015488	71.81	gold quality
gastrocnemius	UBERON:0001388	71.28	gold quality
endometrium	UBERON:0001295	71.27	gold quality
left coronary artery	UBERON:0001626	70.11	gold quality
heart left ventricle	UBERON:0002084	69.08	gold quality
granulocyte	CL:0000094	67.83	gold quality
right atrium auricular region	UBERON:0006631	67.48	gold quality
body of pancreas	UBERON:0001150	67.35	gold quality
body of stomach	UBERON:0001161	67.25	gold quality
transverse colon	UBERON:0001157	67.03	gold quality
urinary bladder	UBERON:0001255	66.63	gold quality
colon	UBERON:0001155	66.21	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.11	gold quality
tibial artery	UBERON:0007610	65.99	gold quality
substantia nigra	UBERON:0002038	65.61	gold quality
amygdala	UBERON:0001876	65.48	gold quality
ascending aorta	UBERON:0001496	65.40	gold quality
esophagus mucosa	UBERON:0002469	65.34	gold quality
left adrenal gland	UBERON:0001234	65.29	gold quality
adult mammalian kidney	UBERON:0000082	65.28	gold quality
lung	UBERON:0002048	65.13	gold quality
right lobe of liver	UBERON:0001114	65.05	gold quality
anterior cingulate cortex	UBERON:0009835	64.97	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.91	gold quality
nucleus accumbens	UBERON:0001882	64.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• An association between the rs188912830 gene variant of miR3202 that targets the MeCP2 protein and lung cancer (LC) was indicated in both subtypes. The rs318039 gene variant of miR1274 that targets DNMT3b was found to be associated with LC subtypes. (PMID:27910778)
• results suggest that high level miR-3202 in T lymphocytes may protect epithelial cells through targeting FAIM2. MiR-3202 might be used as a notable biomarker of chronic obstructive pulmonary disease . (PMID:29208459)
• Antiapoptotic Protein FAIM2 is targeted by miR-3202, and DUX4 via TRIM21, leading to cell death and defective myogenesis. (PMID:35468884)
• Hsa-miR-3202 attenuates Jurkat cell infiltration via MMP2 in primary Sjogren’s syndrome. (PMID:36076347)
• miR-3202 inhibits bronchopulmonary dysplasia-mediated apoptosis and oxidative stress in bronchial epithelial cells via targeting RAG1. (PMID:39067173)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.