MIR320B1

Summary

MIR320B1 (microRNA 320b-1, HGNC:35247) is a microRNA gene on chromosome 1p13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302117 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35247
Approved symbol	MIR320B1
Name	microRNA 320b-1
Location	1p13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-320b-1
Ensembl gene	ENSG00000211543
Ensembl biotype	miRNA
Entrez	100302117
RNAcentral	URS0000D560F4 — miRNA, 72 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390209

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390209 — 1 exons

Exon	Start	End
ENSE00001507636	116671749	116671827

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 78.35.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.35	gold quality
transverse colon	UBERON:0001157	69.42	gold quality
blood	UBERON:0000178	68.75	gold quality
right atrium auricular region	UBERON:0006631	67.81	gold quality
corpus callosum	UBERON:0002336	65.57	gold quality
esophagus mucosa	UBERON:0002469	64.79	gold quality
left ovary	UBERON:0002119	64.77	gold quality
right frontal lobe	UBERON:0002810	63.80	gold quality
left testis	UBERON:0004533	40.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• A possible paracrine role of released platelet miR-320b on endothelial cell intercellular adhesion molecule-1 expression was shown. (PMID:23493781)
• The plasma levels of miR-320b and miR-125b were significantly lower in patients with acute myocardial infarction. (PMID:24627568)
• Waldenstrom macroglobulinemia can be differentially diagnosed using a combination of serum microRNA-320a and microRNA-320b expression levels. (PMID:25428891)
• High MicroRNA-320b expression is associated with metastasis in colorectal cancer. (PMID:25458952)
• Conclude that PDGF enhances mesenchymal stem cell-mediated cardioprotection via a c-Jun/miR-320 signaling mechanism. (PMID:25724494)
• TRIAP1 is regulated by miR-320b and has a role in progression in nasopharyngeal carcinoma (PMID:27428374)
• High miR320b expression is associated with Osteosarcoma Progression. (PMID:28409547)
• Taken together, our data suggested that miR320b might serve as a novel prognostic marker and potential therapeutic target for glioma. (PMID:28656255)
• miR-320b negatively regulates normal human epidermal keratinocyte proliferation by targeting AKT3 to regulate the STAT3 and SAPK/JNK signaling pathways and might participate in the pathogenesis of psoriasis in Chinese Han populations. (PMID:30136020)
• Low miR320b-1 expression is associated with Chronic obstructive pulmonary disease. (PMID:31569706)
• mir-320b rs755613466 T>C and mir-27a rs780199251 G>A polymorphisms and the risk of IVF failure in Kurdish women. (PMID:32006196)
• Promoting effect of long non-coding RNA SNHG1 on osteogenic differentiation of fibroblastic cells from the posterior longitudinal ligament by the microRNA-320b/IFNGR1 network. (PMID:33017569)
• MiR-320b/RAD21 axis affects hepatocellular carcinoma radiosensitivity to ionizing radiation treatment through DNA damage repair signaling. (PMID:33251678)
• MicroRNA-320b Modulates Cholesterol Efflux and Atherosclerosis. (PMID:33536383)
• The MiR-320 Family Is Strongly Downregulated in Patients with COVID-19 Induced Severe Respiratory Failure. (PMID:34638691)
• Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality. (PMID:35122770)
• Circ_NNT suppresses the apoptosis and inflammation in glucose-induced human retinal pigment epithelium by regulating miR-320b/TIMP3 axis in diabetic retinopathy. (PMID:35477026)
• MIR-320a/b inhibits cell viability and cell cycle progression by targeting aryl hydrocarbon receptor nuclear translocator-like in acute promyelocyte leukaemia. (PMID:35979756)
• SNHG1 functions as a ceRNA in hypertrophic scar fibroblast proliferation and apoptosis through miR-320b/CTNNB1 axis. (PMID:36754869)
• MiR-320b aberrant expression enhances the radioresistance of human glioma via upregulated expression of ALDH1A3. (PMID:36996494)
• Placenta-derived exosomes exacerbate beta cell dysfunction in gestational diabetes mellitus through delivery of miR-320b. (PMID:38260139)
• Platelet Microparticle-Derived MiR-320b Inhibits Hypertension with Atherosclerosis Development by Targeting ETFA. (PMID:38556340)

Cross-species orthologs

0 orthologs

Paralogs (5): MIR320A (ENSG00000208037), MIR320E (ENSG00000211513), MIR320C2 (ENSG00000212051), MIR320D2 (ENSG00000221081), MIR320B2 (ENSG00000221406)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.