MIR320B2

Summary

MIR320B2 (microRNA 320b-2, HGNC:35256) is a microRNA gene on chromosome 1q42.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313769 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35256
Approved symbol	MIR320B2
Name	microRNA 320b-2
Location	1q42.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-320b-2
Ensembl gene	ENSG00000221406
Ensembl biotype	miRNA
Entrez	100313769
RNAcentral	URS0000D546CC — miRNA, 71 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408479

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408479 — 1 exons

Exon	Start	End
ENSE00001565114	224257004	224257141

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 87.92.

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	87.92	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	79.12	gold quality
skeletal muscle tissue	UBERON:0001134	79.05	gold quality
monocyte	CL:0000576	77.89	gold quality
adrenal tissue	UBERON:0018303	77.17	gold quality
bone marrow	UBERON:0002371	75.20	gold quality
blood	UBERON:0000178	75.03	gold quality
endometrium	UBERON:0001295	73.33	gold quality
zone of skin	UBERON:0000014	71.97	gold quality
muscle of leg	UBERON:0001383	71.94	gold quality
skin of leg	UBERON:0001511	71.91	gold quality
islet of Langerhans	UBERON:0000006	71.89	gold quality
skin of abdomen	UBERON:0001416	71.89	gold quality
mucosa of stomach	UBERON:0001199	71.67	gold quality
gastrocnemius	UBERON:0001388	71.58	gold quality
vermiform appendix	UBERON:0001154	71.22	gold quality
body of pancreas	UBERON:0001150	70.65	gold quality
corpus callosum	UBERON:0002336	70.61	gold quality
calcaneal tendon	UBERON:0003701	70.59	gold quality
adult mammalian kidney	UBERON:0000082	70.54	gold quality
placenta	UBERON:0001987	70.45	gold quality
ectocervix	UBERON:0012249	70.40	gold quality
lymph node	UBERON:0000029	70.30	gold quality
stomach	UBERON:0000945	70.29	gold quality
myometrium	UBERON:0001296	69.70	gold quality
kidney	UBERON:0002113	69.69	gold quality
metanephros cortex	UBERON:0010533	68.68	gold quality
ascending aorta	UBERON:0001496	68.32	gold quality
body of stomach	UBERON:0001161	68.24	gold quality
tibial artery	UBERON:0007610	68.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• Conclude that PDGF enhances mesenchymal stem cell-mediated cardioprotection via a c-Jun/miR-320 signaling mechanism. (PMID:25724494)
• miR-320b suppresses cell proliferation by targeting c-Myc in human colorectal cancer cells (PMID:26487644)
• TRIAP1 is regulated by miR-320b and has a role in progression in nasopharyngeal carcinoma (PMID:27428374)
• Low miR320b-2 expression is associated with Chronic obstructive pulmonary disease. (PMID:31569706)
• MiR-320b/RAD21 axis affects hepatocellular carcinoma radiosensitivity to ionizing radiation treatment through DNA damage repair signaling. (PMID:33251678)
• Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality. (PMID:35122770)
• Circ_NNT suppresses the apoptosis and inflammation in glucose-induced human retinal pigment epithelium by regulating miR-320b/TIMP3 axis in diabetic retinopathy. (PMID:35477026)
• MIR-320a/b inhibits cell viability and cell cycle progression by targeting aryl hydrocarbon receptor nuclear translocator-like in acute promyelocyte leukaemia. (PMID:35979756)
• MiR-320b aberrant expression enhances the radioresistance of human glioma via upregulated expression of ALDH1A3. (PMID:36996494)
• Placenta-derived exosomes exacerbate beta cell dysfunction in gestational diabetes mellitus through delivery of miR-320b. (PMID:38260139)
• Platelet Microparticle-Derived MiR-320b Inhibits Hypertension with Atherosclerosis Development by Targeting ETFA. (PMID:38556340)

Cross-species orthologs

0 orthologs

Paralogs (5): MIR320A (ENSG00000208037), MIR320E (ENSG00000211513), MIR320B1 (ENSG00000211543), MIR320C2 (ENSG00000212051), MIR320D2 (ENSG00000221081)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.